Effect of the architecture of the left ventricle on the speed of the excitation wave in muscle fibers / Nezlobinsky T. V.,Pravdin S. F.,Katsnelson L. B.,Solovyova O. E. // JETP LETTERS. - 2016. - V. 104, l. 2. - P. 124-129.

ISSN/EISSN:

0021-3640 / 1090-6487

Type:

Article

Abstract:

It is known that preferential paths for the propagation of an electrical excitation wave in the human ventricular myocardium are associated with muscle fibers in tissue. The speed of the excitation wave along a fiber is several times higher than that across the direction of the fiber. To estimate the effect of the architecture and anisotropy of the myocardium of the left ventricle on the process of its electrical activation, we have studied the relation between the speed of the electrical excitation wave in a one-dimensional isolated myocardial fiber consisting of sequentially coupled cardiomyocytes and in an identical fiber located in the wall of a threedimensional anatomical model of the left ventricle. It has been shown that the speed of a wavefront along the fiber in the three-dimensional myocardial tissue is much higher than that in the one-dimensional fiber. The acceleration of the signal is due to the rotation of directions of fibers in the wall and to the position of the excitation wavefront with respect to the direction of this fiber. The observed phenomenon is caused by the approach of the excitable tissue with rotational anisotropy in its properties to a pseudoisotropic tissue.

Author keywords:

MODEL; ORIENTATION; HEART

DOI:

10.1134/S0021364016140101

Web of Science ID:

ISI:000385020700010

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUL
Publisher	MAIK NAUKA/INTERPERIODICA/SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013-1578 USA
Language	English
EISSN	1090-6487
Keywords-Plus	MODEL; ORIENTATION; HEART
Research-Areas	Physics
Web-of-Science-Categories	Physics, Multidisciplinary
Author-Email	nezlobinsky@yandex.ru
ResearcherID-Numbers	Pravdin, Sergei/O-8888-2016 Solovyova, Olga/T-8232-2017
ORCID-Numbers	Pravdin, Sergei/0000-0003-4053-8895
Funding-Acknowledgement	Russian Science Foundation {[}14-35-00005]
Funding-Text	We are grateful to N.A. Vikulova and A.D. Khokhlova for the discussion of the formulation of the problems and results. This work was supported by the Russian Science Foundation (project no. 14-35-00005).
Number-of-Cited-References	9
Usage-Count-Since-2013	1
Journal-ISO	Jetp Lett.
Doc-Delivery-Number	DY3UO