Scroll wave dynamics in a model of the heterogeneous heart / Konovalov P. V.,Pravdin S. F.,Solovyova O. E.,Panfilov A. V. // JETP LETTERS. - 2016. - V. 104, l. 2. - P. 130-134.

ISSN/EISSN:

0021-3640 / 1090-6487

Type:

Article

Abstract:

Scroll waves are found in physical, chemical and biological systems and underlie many significant processes including life-threatening cardiac arrhythmias. The theory of scroll waves predicts scroll wave dynamics should be substantially affected by heterogeneity of cardiac tissue together with other factors including shape and anisotropy. In this study, we used our recently developed analytical model of the human ventricle to identify effects of shape, anisotropy, and regional heterogeneity of myocardium on scroll wave dynamics. We found that the main effects of apical-base heterogeneity were an increased scroll wave drift velocity and a shift towards the region of maximum action potential duration. We also found that transmural heterogeneity does not substantially affect scroll wave dynamics and only in extreme cases changes the attractor position.

Author keywords:

ISOLATED RABBIT HEART; VENTRICULAR-TACHYCARDIA; REPOLARIZATION; DISPERSION; MECHANISM; REENTRY; DRIFT

DOI:

10.1134/S0021364016140034

Web of Science ID:

ISI:000385020700011

Соавторы в МНС:

—

Другие поля

Поле	Значение
Month	JUL
Publisher	MAIK NAUKA/INTERPERIODICA/SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013-1578 USA
Language	English
EISSN	1090-6487
Keywords-Plus	ISOLATED RABBIT HEART; VENTRICULAR-TACHYCARDIA; REPOLARIZATION; DISPERSION; MECHANISM; REENTRY; DRIFT
Research-Areas	Physics
Web-of-Science-Categories	Physics, Multidisciplinary
Author-Email	konpav@gmail.com
ResearcherID-Numbers	Solovyova, Olga/T-8232-2017 Pravdin, Sergei/O-8888-2016 Panfilov, Alexander/G-8459-2016
ORCID-Numbers	Pravdin, Sergei/0000-0003-4053-8895 Panfilov, Alexander/0000-0003-2643-642X
Funding-Acknowledgement	Russian Science Foundation {[}14-35-00005]
Funding-Text	This work was supported by the Russian Science Foundation (project no. 14-35-00005). We are thankful to the Interuniversity Attraction Poles Program of Belgian Government for help in preparation of the English version of the manuscript.
Number-of-Cited-References	15
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	4
Journal-ISO	Jetp Lett.
Doc-Delivery-Number	DY3UO