Load-Dependency in Mechanical Properties of Subepicardial and Subendocardial Cardiomyocytes / Khokhlova Anastasia,Iribe Gentaro,Solovyova Olga // . - 2015. - V. 42, l. . - P. 965-968.

ISSN/EISSN:

0276-6574 / нет данных

Type:

Proceedings Paper

Abstract:

Electrical and mechanical properties of myocardium vary transmurally in the left ventricular wall. Regional differences in the mechanical environment of cardiomyocytes may potentially contribute to this heterogeneity due to mechano-electric feedback. In the present study, we investigate transmural differences in active and passive tensions at different preloads between the subepicardial (EPI) and subendocardial (ENDO) cells isolated from mouse left ventricle, using our recently developed single cell stretch method where each cell end was held by a pair of carbon fibers to apply various extent of preload to the cells. To predict underlying mechanisms of the transmural differences, we used our electromechanical EPI and ENDO cell models to simulate experimentally obtained results. Wet experiments showed that both passive and active tensions at different preloads are higher in ENDO cardiomyocytes, indicating higher stiffness and contractility in ENDO cells compared to EPI cells. Our mathematical models reproduce experimental results, suggesting differences in the kinetics of cross bridges and calcium-troponin C complexes in ENDO and EPI models may essentially contribute to the differences in mechanical properties between the cells.

Author keywords:

FORCE-LENGTH RELATIONS; VENTRICULAR MYOCYTES; TENSION; HEARTS; MUSCLE

DOI:

нет данных

Web of Science ID:

ISI:000380374700243

Соавторы в МНС:

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Другие поля

Поле	Значение
Editor	Murray, A
Booktitle	2015 COMPUTING IN CARDIOLOGY CONFERENCE (CINC)
Series	Computing in Cardiology Series
Note	2015 Comp in Cardiol Conference (CinC), Comp in Cardiol 2015, nice, FRANCE, SEP 06-09, 2015
Publisher	IEEE
Address	345 E 47TH ST, NEW YORK, NY 10017 USA
Language	English
ISBN	978-1-5090-0685-4
Keywords-Plus	FORCE-LENGTH RELATIONS; VENTRICULAR MYOCYTES; TENSION; HEARTS; MUSCLE
Research-Areas	Computer Science; Engineering
Web-of-Science-Categories	Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary; Engineering, Biomedical
Author-Email	a.khokhlova@iiip.uran.ru
ResearcherID-Numbers	Solovyova, Olga/T-8232-2017
Number-of-Cited-References	11
Doc-Delivery-Number	BF1CZ