Synthesis and biological activity of novel N-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl) amides derivatives / Huo Jing-Qian,Ma Liu-Yong,Zhang Zhe,Fan Zhi-Jin,Zhang Jin-Lin,Beryozkina Tetyana V.,Bakulev Vasiliy A. // CHINESE CHEMICAL LETTERS. - 2016. - V. 27, l. 9. - P. 1547-1550.

ISSN/EISSN:

1001-8417 / 1878-5964

Type:

Article

Abstract:

A series of novel N-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl) amides derivatives were designed and synthesized. Their structures were confirmed by H-1 NMR, C-13 NMR and HRMS. All title compounds were evaluated for their herbicidal and antifungal activities. Preliminary bioassay results indicated that the title compounds showed good to moderate herbicidal activity at 1000 mg/L. Compound 6q presented the best activity against Digitaria sanguinalis (L) Scop., Amaranthus retroflexus L. and Arabidopsis thaliana with an inhibition degree of five. Compound 6d also showed an inhibition degree of five against D. sanguinalis. In addition, at 50 mg/L, most compounds exhibited good in vitro antifungal activity against Sclerotinia sclerotiorum, with compound 6c showing over 90\% antifungal activity against S. sclerotiorum and Pellicularia sasakii. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Author keywords:

Amides derivative; Pyrazole; Furan; Synthesis; Herbicidal activity; Fungicidal activity DRUG DISCOVERY; TRANSKETOLASE; RESISTANCE; MANAGEMENT; 1,2,3-TRIAZOLES

DOI:

10.1016/j.cclet.2016.06.019

Web of Science ID:

ISI:000384789100015

Соавторы в МНС:

Другие поля

Поле	Значение
Month	SEP
Publisher	ELSEVIER SCIENCE INC
Address	360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
Language	English
EISSN	1878-5964
Keywords-Plus	DRUG DISCOVERY; TRANSKETOLASE; RESISTANCE; MANAGEMENT; 1,2,3-TRIAZOLES
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	fanzj@nankai.edu.cn zhangjinlin@hebau.edu.cn
Funding-Acknowledgement	National Natural Science Foundation of China {[}31171877, 31571991, 21372132]; International Science \& Technology Cooperation Program of China {[}2014DFR41030]
Funding-Text	This work was financially supported by the National Natural Science Foundation of China (Nos. 31171877, 31571991, 21372132) and the International Science \& Technology Cooperation Program of China (No. 2014DFR41030).
Number-of-Cited-References	25
Usage-Count-Last-180-days	6
Usage-Count-Since-2013	15
Journal-ISO	Chin. Chem. Lett.
Doc-Delivery-Number	DY0LU