Synthesis of enantiomers of N-(2-aminopurin-6-yl) amino acids / Krasnov V. P.,Vigorov A. Yu.,Gruzdev D. A.,Levit G. L.,Demin A. M.,Nizova I. A.,Tumashov A. A.,Sadretdinova L. Sh.,Gorbunov E. B.,Charushin V. N. // RUSSIAN CHEMICAL BULLETIN. - 2015. - V. 64, l. 9. - P. 2106-2113.

ISSN/EISSN:

1066-5285 / 1573-9171

Type:

Article

Abstract:

Nonracemic N-(2-aminopurin-6-yl)-substituted amino acids were synthesized by nucleophilic substitution of chlorine atom in 2-acetamido-6-chloropurine upon treatment with amino acid tert-butyl esters and subsequent removal of protecting groups. Their enantiomeric composition was determined by HPLC on chiral stationary phases.

Author keywords:

purines; amino acids; enantiomers; racemization; high performance liquid chromatography BIOLOGICAL-ACTIVITY; PURINE DERIVATIVES; NUCLEOSIDE ANALOGS; PRODRUGS; KINASE; AGENTS; TRANSPORTER; INHIBITORS; ADENOSINE; DELIVERY

DOI:

нет данных

Web of Science ID:

ISI:000383958300015

Соавторы в МНС:

Другие поля

Поле	Значение
Month	SEP
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-9171
Keywords-Plus	BIOLOGICAL-ACTIVITY; PURINE DERIVATIVES; NUCLEOSIDE ANALOGS; PRODRUGS; KINASE; AGENTS; TRANSPORTER; INHIBITORS; ADENOSINE; DELIVERY
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	ca@ios.uran.ru
Funding-Acknowledgement	Russian Science Foundation {[}14-13-01077]
Funding-Text	This work was financially supported by the Russian Science Foundation (Grant 14-13-01077).
Number-of-Cited-References	46
Usage-Count-Since-2013	2
Journal-ISO	Russ. Chem. Bull.
Doc-Delivery-Number	DW9EH