2-Morpholino-5-Phenyl-6H-1,3,4-Thiadiazine Corrects Metabolic Disorders during the Development of Alloxan Diabetes Mellitus in Rats / Emelianov V. V.,Savateeva E. A.,Sidorova L. P.,Tseitler T. A.,Gette I. F.,Bulavintseva T. S.,Smirnykh S. E.,Maksimova N. E.,Mochulskaya N. N.,Chupakhin O. N.,Chereshnev V. A. // BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE. - 2016. - V. 162, l. 1. - P. 35-37.

ISSN/EISSN:

0007-4888 / 1573-8221

Type:

Article

Abstract:

Metabolic disorders were evaluated in rats with alloxan diabetes mellitus after administration of 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine (compound L-17). Administration of L-17 reduced the severity of metabolic disorders associated with diabetes mellitus. At the end of the experiment, the concentration of glucose, glycated hemoglobin, malonic dialdehyde, and catalase activity were significantly higher and peroxidase activity was significantly lower in the group of animals receiving L-17. The decrease of glycemia, glucose concentration, and glycated hemoglobin content was reached by the 3rd-4th week of the experiment. These data suggest that correction of biochemical parameters in rats with alloxan diabetes was reached after administration of L-17 for at least 3 weeks.

Author keywords:

diabetes mellitus; 1,3,4-thiadiazines; oxidative stress; protein glycation GLYCATION

DOI:

10.1007/s10517-016-3538-4

Web of Science ID:

ISI:000390027400010

Соавторы в МНС:

Другие поля

Поле	Значение
Month	NOV
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-8221
Keywords-Plus	GLYCATION
Research-Areas	Research \& Experimental Medicine
Web-of-Science-Categories	Medicine, Research \& Experimental
Author-Email	evvd@list.ru
ResearcherID-Numbers	Chereshnev, Valerii/P-7704-2017
ORCID-Numbers	Chereshnev, Valerii/0000-0003-4329-147X
Funding-Acknowledgement	Russian Science Foundation {[}16-15-00039]; Government of the Russian Federation {[}211, 02.A03.21.0006]; Presidium of the Ural Division of Russian Academy of Sciences; Russian Foundation for Basic Research {[}16-04-20060]
Funding-Text	The work was supported by the Russian Science Foundation (project No. 16-15-00039). The study was presented at the conference ``Experimental and Computer Biomedicine{''} (April 10-12, 2016, Ekaterinburg) organized by the Ural Federal University and Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, and supported by the Government of the Russian Federation (No. 211 and No. 02.A03.21.0006), the Presidium of the Ural Division of Russian Academy of Sciences, and Russian Foundation for Basic Research (grant No. 16-04-20060).
Number-of-Cited-References	10
Usage-Count-Last-180-days	5
Usage-Count-Since-2013	11
Journal-ISO	Bull. Exp. Biol. Med.
Doc-Delivery-Number	EF0PG