Reaction of Lymphoid Organs to Injection of Iron-Carbon Nanoparticles / Khramtsova Yu. S.,Tyumentseva N. V.,Yushkov B. G.,Silant'eva E. A.,Medvedeva S. Yu.,Byzov I. V.,Uimin M. A.,Ermakov A. E. // BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE. - 2016. - V. 162, l. 2. - P. 252-254.

ISSN/EISSN:
0007-4888 / 1573-8221
Type:
Article
Abstract:
The distribution of iron-carbon nanoparticles in FeC-DSPE-PEG-2000 modification (micellar particles with structure (Fe) core-carbon shell; PEG-based coating) is studied. The greater part of the nanoparticles accumulated in the spleen and liver, a small amount in the lungs, and the minimum amount in the thymus. The structural changes in the lymphoid organs were minor and involved only the microcirculatory bed. Analysis of the peripheral blood showed manifest anemia, thrombocytopenia, and leukocytosis.
Author keywords:
iron-carbon nanoparticles; biodistribution; lymphoid organs CANCER; TUMOR; NANOMEDICINE; DELIVERY; DRUGS
DOI:
10.1007/s10517-016-3588-7
Web of Science ID:
ISI:000390026800020
Соавторы в МНС:
Другие поля
Поле Значение
Month DEC
Publisher SPRINGER
Address 233 SPRING ST, NEW YORK, NY 10013 USA
Language English
EISSN 1573-8221
Keywords-Plus CANCER; TUMOR; NANOMEDICINE; DELIVERY; DRUGS
Research-Areas Research \& Experimental Medicine
Web-of-Science-Categories Medicine, Research \& Experimental
Author-Email hramtsova15@mail.ru
ResearcherID-Numbers Uimin, Mikhail/K-1319-2013 Byzov, Ilya/J-7850-2013
ORCID-Numbers Uimin, Mikhail/0000-0003-3906-8101 Byzov, Ilya/0000-0003-1940-4892
Funding-Acknowledgement Government of the Russian Federation {[}211, 02.A03.21.0006]; Presidium of the Ural Division of the Russian Academy of Sciences; Russian Foundation for Basic Research {[}16-04-20060]
Funding-Text The study was supported by the Government of the Russian Federation (resolution No. 211, contract No. 02.A03.21.0006) and presented at the conference ``Experimental and Computer Biomedicine{''} (April 10-12, 2016, Ekaterinburg) organized by the Ural Federal University and Institute of Immunology and Physiology and supported by the Government of the Russian Federation (p. No. 211, No. 02.A03.21.0006), Presidium of the Ural Division of the Russian Academy of Sciences, and Russian Foundation for Basic Research (grant No. 16-04-20060).
Number-of-Cited-References 13
Usage-Count-Since-2013 1
Journal-ISO Bull. Exp. Biol. Med.
Doc-Delivery-Number EF0PB