Reaction of lymphoid organs to injection of Iron-Carbon nanoparticles / Khramtsova Y.S., Tyumentseva N.V., Yushkov B.G., Silant’eva E.A., Medvedeva S.Y., Byzov I.V., Uimin M.A., Ermakov A.E. // Bulletin of Experimental Biology and Medicine. - 2016. - V. 162, l. 2. - P. 252-254.

ISSN:
00074888
Type:
Article
Abstract:
The distribution of iron-carbon nanoparticles in FeC-DSPE-PEG-2000 modification (micellar particles with structure (Fe) core-carbon shell; PEG-based coating) is studied. The greater part of the nanoparticles accumulated in the spleen and liver, a small amount in the lungs, and the minimum amount in the thymus. The structural changes in the lymphoid organs were minor and involved only the microcirculatory bed. Analysis of the peripheral blood showed manifest anemia, thrombocytopenia, and leukocytosis. © 2016 Springer Science+Business Media New York.
Author keywords:
Biodistribution; Iron-carbon nanoparticles; Lymphoid organs
Index keywords:
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000); carbon; drug carrier; eosin; hematoxylin; iron; macrogol derivative; magnetite nanoparticle; phosphatidylethanolam
DOI:
10.1007/s10517-016-3588-7
Смотреть в Scopus:
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011957243&doi=10.1007%2fs10517-016-3588-7&partnerID=40&md5=c155cd5b8db046e3832f7fada24ca756
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Link https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011957243&doi=10.1007%2fs10517-016-3588-7&partnerID=40&md5=c155cd5b8db046e3832f7fada24ca756
Affiliations Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Russian Federation; B. N. Eltsin Ural Federal University, Russian Federation; M. N. Mikheev Institute of Metal Physics, The Ural Division of the Russian Academy of Sciences, Russian Federation; Institute of Medical Cell Technologies, Ekaterinburg, Russian Federation
Author Keywords Biodistribution; Iron-carbon nanoparticles; Lymphoid organs
Chemicals/CAS carbon, 7440-44-0; eosin, 17372-87-1, 51395-88-1, 548-26-5; hematoxylin, 517-28-2; iron, 14093-02-8, 53858-86-9, 7439-89-6; phosphatidylethanolamine, 1405-71-6; 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000); Carbon; Drug Carriers; Eosine Yellowish-(YS); Hematoxylin; Iron; Magnetite Nanoparticles; Phosphatidylethanolamines; Polyethylene Glycols
Funding Details 16-04-20060, RFBR, Russian Foundation for Basic Research
Funding Text The study was supported by the Government of the Russian Federation (resolution No. 211, contract No. 02.A03.21.0006) and presented at the conference “Experimental and Computer Biomedicine” (April 10-12, 2016, Ekaterinburg) organized by the Ural Federal University and Institute of Immunology and Physiology and supported by the Government of the Russian Federation (p. No. 211, No. 02.A03.21.0006), Presidium of the Ural Division of the Russian Academy of Sciences, and Russian Foundation for Basic Research (grant No. 16-04-20060).
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Correspondence Address Khramtsova, Y.S.; Institute of Immunology and Physiology, Ural Division of the Russian Academy of SciencesRussian Federation; email: hramtsova15@mail.ru
Publisher Springer New York LLC
CODEN BEXBA
PubMed ID 27905033
Language of Original Document English
Abbreviated Source Title Bull. Exp. Biol. Med.
Source Scopus