Effect of tissue macrophage destruction products on hematopoietic stem cells [O vliianii produktov destruktsii tkanevykh makrofagov na stvolovye krovetvornye kletki.] / Privalova L.I., Iushkov B.G., Katsnel'son B.A. // Byulleten Eksperimentalnoi Biologii i Meditsiny. - 1979. - V. 87, l. 4. - P. 345-347.

ISSN:

03659615

Type:

Article

Abstract:

Products of mouse peritoneal macrophage destruction (PMD) obtained by aseptic freezing-thawing of the cells, repeated thrice, were found to elicit in syngeneic mice injected with PMD intraperitoneally an increase of CFUs count in the hemopoietic bone marrow tissue and the spleen, as demonstrated by the Till and McCullooch technique. This proved to be a true increase since the transplatned stem cell fraction sorbed by the recipient's spleen was relatively lower in donor mice given PMD than in the control. Although PMD caused an increase of both erythropoietic (E) and granulocytopoietic-monocytic (G) colonies number, the E/G ratio was decreased; one of the mechanisms of the described effect could be the influence of PMD on the hemopoiesis-inducing microenvironment, as the same effects were obtained in mice injected repeatedly with PMD prior to the transplantation of bone marrow tissue of normal donors. Other possible mechanisms of these effects were analyzed, with consideration to the fact that in experiments with preincubation of bone marrow tissue with PMD prior to injection to the lethally irradiated mice no direct stimulating influence of PMD on the stem cell could be revealed.

Author keywords:

Index keywords:

animal; article; clonogenic assay; freezing; hematopoietic stem cell; macrophage; mouse; mouse strain; Animal; Colony-Forming Units Assay; English Abstract; Freezing; Hematopoietic Stem Cells; Macroph

DOI:

нет данных

Смотреть в Scopus:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0018459566&partnerID=40&md5=1cb6251fe6122e98a77aaf31d70b788c

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Другие поля

Поле	Значение
Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0018459566&partnerID=40&md5=1cb6251fe6122e98a77aaf31d70b788c
Correspondence Address	Privalova, L.I.
PubMed ID	435626
Language of Original Document	Russian
Abbreviated Source Title	Biull Eksp Biol Med
Source	Scopus