Synthesis and fungicidal activity of 3,4-dichloroisothiazole based strobilurins as potent fungicide candidates / Chen Lai,Guo Xiao-Feng,Fan Zhi-Jin,Zhang Nai-Lou,Zhu Yu-Jie,Zhang Zhi-Ming,Khazhieva Inna,Yurievich Morzherin Y.,Belskaya Nataliya P.,Bakulev Vasiliy A. // RSC ADVANCES. - 2017. - V. 7, l. 6. - P. 3145-3151.

ISSN/EISSN:

2046-2069 / нет данных

Type:

Article

Abstract:

A series of 3,4-dichloroisothiazole based novel strobilurin analogs were designed and synthesized, and their structures were elucidated by NMR and HRMS, and the typical crystal structure was determined by X-ray diffraction for validation. Results from different biological assays suggested that most target compounds displayed very good fungicidal activity against one or multiple plant pathogens in vitro and in vivo. Among them, compounds 6d, 6g and 8d showed a broad spectrum of fungicidal activity. Further field experiments indicated that compound 8d displayed better efficacy against Sphaerotheca fuliginea than commercial standards azoxystrobin and trifloxystrobin, and better efficacy against Pseudoperonospora cubensis than trifloxystrobin. Overall, a new fungicidal candidate for plant disease management was discovered in this study.

Author keywords:

RESISTANCE; CHEMISTRY

DOI:

10.1039/c6ra25520e

Web of Science ID:

ISI:000393749200013

Соавторы в МНС:

Другие поля

Поле	Значение
Publisher	ROYAL SOC CHEMISTRY
Address	THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Language	English
Keywords-Plus	RESISTANCE; CHEMISTRY
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	fanzj@nankai.edu.cn v.a.bakulev@urfu.ru
ResearcherID-Numbers	Belskaya, Nataliya/S-3953-2017
ORCID-Numbers	Belskaya, Nataliya/0000-0002-2509-7916
Funding-Acknowledgement	International Science \& Technology Cooperation Program of China {[}2014DFR41030]; National Natural Science Foundation of China {[}21372132, 31571991]; ``111{''} Project of Ministry of Education of China {[}B06005]; Tianjin Natural Science Foundation {[}14JCYBJC20400]
Funding-Text	This research was in part financial supported by the International Science \& Technology Cooperation Program of China (Grant no. 2014DFR41030), the National Natural Science Foundation of China (No. 21372132 and 31571991), the ``111{''} Project of Ministry of Education of China (Project No. B06005) and Tianjin Natural Science Foundation (No.: 14JCYBJC20400). V. A. Bakulev thanks The Ministry of Education and Science of the Russian Federation (State task 4.1626.2014/K).
Number-of-Cited-References	28
Usage-Count-Last-180-days	2
Usage-Count-Since-2013	3
Journal-ISO	RSC Adv.
Doc-Delivery-Number	EK2HU