Synthesis of ethyl 4-(isoxazol-4-yl)-2,4-dioxobutanoates from ethyl 5-aroyl-4-pyrone-2-carboxylates and hydroxylamine / Obydennov Dmitrii L.,Khammatova Liliya R.,Sosnovskikh Vyacheslav Ya. // MENDELEEV COMMUNICATIONS. - 2017. - V. 27, l. 2. - P. 172-174.

ISSN/EISSN:

0959-9436 / 1364-551X

Type:

Article

Abstract:

Ethyl 5-aroyl-4-pyrone-2-carboxylates react with hydroxyl amine in ethanol at -20 degrees C for 30 days to produce ethyl 4-(5-arylisoxazol-4-yl)-2,4-dioxobutanoates (yields 20-67\%). The similar reaction of diethyl 4-pyrone-2,5-dicarboxylate gives ethyl 4-oxo-4H-pyrano{[}3,4-d]isoxazole-6-carboxylate in 37\% yield.

Author keywords:

DUAL INHIBITORS; RIBONUCLEASE H; DIKETO ACID; INTEGRASE; REARRANGEMENT; HETEROCYCLES; DERIVATIVES; CHEMISTRY; DOMAIN

DOI:

10.1016/j.mencom.2017.03.022

Web of Science ID:

ISI:000398749600022

Соавторы в МНС:

Другие поля

Поле	Значение
Month	MAR-APR
Publisher	ELSEVIER SCIENCE BV
Address	PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Language	English
EISSN	1364-551X
Keywords-Plus	DUAL INHIBITORS; RIBONUCLEASE H; DIKETO ACID; INTEGRASE; REARRANGEMENT; HETEROCYCLES; DERIVATIVES; CHEMISTRY; DOMAIN
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	dobydennov@mail.ru
Number-of-Cited-References	23
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	1
Journal-ISO	Mendeleev Commun.
Doc-Delivery-Number	ER4DP