Assessment of Comparative Toxicity of Nano- and Microparticles Magnetite / Katsnelson B. A.,Privalova L. I.,Degtyareva T. D.,Kuzmin S. V.,Sutunkova M. P.,Minigalieva I. A.,Kireyeva E. P.,Khodos M. Y.,Shur V. Y.,Nikolaeva E. V.,Valamina I. E.,Tulakina L. G.,Pichugova S. V.,Beykin J. B. // . - 2011. - V. , l. . - P. 537-540.

ISSN/EISSN:

нет данных / нет данных

Type:

Proceedings Paper

Abstract:

The key mechanism of pulmonary region's clearance from deposited particles is recruitment of phagocytizing cells on its free surface. Phagocytosis hinders penetration of these particles into pulmonary interstices and thus promotes mucociliary clearancetil. The alveolar macrophage (AM) is the main cell effector of phagocytosis-mediated pulmonary clearance, the neutrophile leukocyte (NL) being the most important auxiliary one. NLs recruitment is controlled by the number of destroyed AMs. That's why the intensity of NLs recruitment toward deposited particles depends quantitatively on their cytotoxicity for macrophages({[}1-5]). Thus NL/AM ratio may be used as a criterion of comparative cytotoxicity of particles. Another nano-toxicological problem of theoretical and practical importance is the size-dependence of the comparative resorptive toxicity of particles of substances that are deemed innocuous in bulk.

Author keywords:

nanoparticles; magnetite; subchronic toxicity CHRONIC INHALATION EXPOSURE; MULTICOMPARTMENTAL MODEL; QUARTZ DUST; CYTOTOXICITY; PARTICLES

DOI:

нет данных

Web of Science ID:

ISI:000394061000141

Соавторы в МНС:

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Другие поля

Поле	Значение
Editor	Laudon, M and Romanowicz, B
Booktitle	NANOTECHNOLOGY 2011: BIO SENSORS, INSTRUMENTS, MEDICAL, ENVIRONMENT AND ENERGY, NSTI-NANOTECH 2011, VOL 3
Note	NSTI Nanotechnology Conference and Expo, Boston, MA, JUN 13-16, 2011
Organization	Clean Technol \& Sustainable Ind Org; European Patent Off; Greenberg Traurig; Innovat \& Mat Sci Inst; Jackson Walker LLP; Linde Nanomaterials; Lockheed Martin; Nano Sci \& Technol Inst; Nano Tech Japan; NanoEurope Fair \& Conf; Nanpolis Suzhou, Suzhou Nanotech Co Ltd; Natl Inst Standards \& Technol; Ctr Nanoscale Sci \& Technol; Fraunhofer, Res Germany; TechConnect; Technol Innovat Program; Canadian Trade Commiss Serv; Italian Trade Commiss
Publisher	CRC PRESS-TAYLOR \& FRANCIS GROUP
Address	6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA
Language	English
ISBN	978-1-4398-7138-6
Keywords-Plus	CHRONIC INHALATION EXPOSURE; MULTICOMPARTMENTAL MODEL; QUARTZ DUST; CYTOTOXICITY; PARTICLES
Research-Areas	Energy \& Fuels; Engineering; Science \& Technology - Other Topics; Research \& Experimental Medicine; Materials Science
Web-of-Science-Categories	Energy \& Fuels; Engineering, Environmental; Nanoscience \& Nanotechnology; Medicine, Research \& Experimental; Materials Science, Biomaterials
ResearcherID-Numbers	Shishkina, Ekaterina/I-1829-2017 Shur, Vladimir/J-9078-2015
ORCID-Numbers	Shishkina, Ekaterina/0000-0002-2574-7472
Number-of-Cited-References	6
Doc-Delivery-Number	BG9XC