Heterocycles of Natural Origin as Non-Toxic Reagents for Cross-Linking of Proteins and Polysaccharides / Tokareva Maria I.,Ivantsova Maria N.,Mironov Maxim A. // CHEMISTRY OF HETEROCYCLIC COMPOUNDS. - 2017. - V. 53, l. 1. - P. 21-35.

ISSN/EISSN:

0009-3122 / 1573-8353

Type:

Article

Abstract:

Chemical cross-linking of structural biopolymers, such as collagen, hyaluronic acid, and cellulose, plays a significant role in the preparation of new materials for bioengineering and directed delivery of medicinal compounds. However, the currently known methods for the modification of biopolymers by using synthetic reagents often lead to derivatives with noticeable toxicity. In order to design biomaterials that are fully compatible with human tissues, many recent studies have relied on the use of natural heterocyclic compounds isolated from plants and animals. Examples of such heterocycles include genipin, flavonoids found in foods (catechins, proanthocyanidins), and desmosine analogs. The applications of heterocycles in bioengineering for linking natural proteins and polysaccharides is a new and very promising direction in the chemistry of heterocyclic compounds, as illustrated by the large number of publications over the last decade.

Author keywords:

biopolymers; chitosan; collagen; desmosine; flavonoids; genipin; polysaccharides; proanthocyanidins GREEN TEA EXTRACT; DENTIN BOND STRENGTH; LINKED CHITOSAN HYDROGELS; IN-VITRO EVALUATION; HEART-VALVE MATRIX; MECHANICAL-PROPERTIES; DRUG-DELIVERY; DEMINERALIZED DENTIN; BIOLOGICAL TISSUE; AMINO-ACIDS

DOI:

10.1007/s10593-017-2016-x

Web of Science ID:

ISI:000394972700004

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JAN
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-8353
Keywords-Plus	GREEN TEA EXTRACT; DENTIN BOND STRENGTH; LINKED CHITOSAN HYDROGELS; IN-VITRO EVALUATION; HEART-VALVE MATRIX; MECHANICAL-PROPERTIES; DRUG-DELIVERY; DEMINERALIZED DENTIN; BIOLOGICAL TISSUE; AMINO-ACIDS
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	m.a.mironov@urfu.ru
ORCID-Numbers	, Maria/0000-0002-2389-0523
Funding-Acknowledgement	Ministry of Education and Science of the Russian Federation {[}4.1626.2014/K]
Funding-Text	The work was performed with financial support from the Ministry of Education and Science of the Russian Federation (State contract No. 4.1626.2014/K).
Number-of-Cited-References	182
Usage-Count-Last-180-days	9
Usage-Count-Since-2013	10
Journal-ISO	Chem. Heterocycl. Compds.
Doc-Delivery-Number	EL9XF