Polyfluorinated salicylic acid derivatives as analogs of known drugs: Synthesis, molecular docking and biological evaluation / Shchegol'kov E. V.,Shchur I. V.,Burgart Ya. V.,Saloutin V. I.,Trefilova A. N.,Ljushina G. A.,Solodnikov S. Yu.,Markova L. N.,Maslova V. V.,Krasnykh O. P.,Borisevich S. S.,Khursan S. L. // BIOORGANIC \& MEDICINAL CHEMISTRY. - 2017. - V. 25, l. 1. - P. 91-99.

ISSN/EISSN:

0968-0896 / 1464-3391

Type:

Article

Abstract:

We have developed the convenient methods for synthesis of polyfluorosalicylic acids and their derivatives. For the first time the biological properties of polyfluorosalicylates were investigated in vitro (permeability through the biological membranes, COX-1 inhibitory action) and in vivo (anti-inflammatory, analgesic activities, acute toxicity). Molecular docking of polyfluorinated salicylates confirmed in vitro and in vivo experiments. (C) 2016 Elsevier Ltd. All rights reserved.

Author keywords:

Polyfluoronated salicylates; Nucleophilic substitution; ortho-Methoxylation; Molecular docking; Anti-inflammatory and analgesic activities; COX-1 inhibition; Toxicity; Permeability RANDOMIZED CONTROLLED-TRIALS; MYOCARDIAL-INFARCTION; MEDICINAL CHEMISTRY; CANCER INCIDENCE; DAILY ASPIRIN; FLUORINE; PHARMACEUTICALS; METASTASIS

DOI:

10.1016/j.bmc.2016.10.014

Web of Science ID:

ISI:000397052800011

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JAN 1
Publisher	PERGAMON-ELSEVIER SCIENCE LTD
Address	THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Language	English
EISSN	1464-3391
Keywords-Plus	RANDOMIZED CONTROLLED-TRIALS; MYOCARDIAL-INFARCTION; MEDICINAL CHEMISTRY; CANCER INCIDENCE; DAILY ASPIRIN; FLUORINE; PHARMACEUTICALS; METASTASIS
Research-Areas	Biochemistry \& Molecular Biology; Pharmacology \& Pharmacy; Chemistry
Web-of-Science-Categories	Biochemistry \& Molecular Biology; Chemistry, Medicinal; Chemistry, Organic
Author-Email	schegolkov@ios.uran.ru
ResearcherID-Numbers	Burgart, Yanina/T-8025-2017 Shchegol'kov, Evgenii/H-6790-2015
ORCID-Numbers	Burgart, Yanina/0000-0001-6061-2410 Shchegol'kov, Evgenii/0000-0001-6611-2855 Khursan, Sergey/0000-0003-1879-944X
Funding-Acknowledgement	Russian Scientific Foundation {[}16-13-10255]
Funding-Text	This work was supported by the Russian Scientific Foundation (Grant No. 16-13-10255). The authors express gratitude to Mrs Elvira Pozjumko for helpful assistance at PAMPA experiment. All calculations were carried out on a cluster in the regional center for shared computer equipment at the Ufa Institute of Chemistry RAS.
Number-of-Cited-References	59
Usage-Count-Last-180-days	8
Usage-Count-Since-2013	10
Journal-ISO	Bioorg. Med. Chem.
Doc-Delivery-Number	EP0BW