Plasmonic photothermal therapy of atherosclerosis with nanoparticles: Long-term outcomes and safety in NANOM-FIM trial / Kharlamov A.N., Feinstein J.A., Cramer J.A., Boothroyd J.A., Shishkina E.V., Shur V. // Future Cardiology. - 2017. - V. 13, l. 4. - P. 345-363.

ISSN:
14796678
Type:
Article
Abstract:
Aim: The safety options in nanomedicine raise an issue of the optimal niche at the real-world clinical practice. Methods: This is an observational prospective cohort analysis of the 5-year clinical outcomes at the intention-to-treat population (nano vs ferro vs stenting; n = 180) of NANOM first-in-man trial (NCT01270139). Results: Mortality (6 vs 9 vs 10 cases of cardiac death in groups, p < 0.05), major adverse cardiovascular events (14.3 vs 20.9 vs 22.9%, p = 0.04), late thrombosis (2 vs 4 vs 6, p < 0.05) and target lesion revascularization (3.8 vs 4.8 vs 5.7%, p = 0.04) were significantly higher in ferro group and stent control at 60 months. Conclusion: NANOM first-in-man trial demonstrates high safety with better rate of mortality, major adverse cardiovascular events and target lesion revascularization at the long-term follow-up if compare with stent XIENCE V. © 2017 Future Medicine Ltd.
Author keywords:
long-term outcomes; nanomedicine; regression of atherosclerosis; safety; silica-gold nanoparticles
Index keywords:
нет данных
DOI:
10.2217/fca-2017-0009
Смотреть в Scopus:
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85022179501&doi=10.2217%2ffca-2017-0009&partnerID=40&md5=f0b9cf8b5faf7ebec134a6875789edaa
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Affiliations Department of Interventional Cardiovascular Biomedicine, De Haar Research Foundation, Handelsplein 15, Rotterdam, Netherlands; Departments of Science and Interventional Cardiology, Ural Institute of Cardiology, 8th March Street, 78A, Yekaterinburg, Russian Federation; Ural Center of Modern Nanotechnologies, School of Natural Sciences and Mathematics, Ural Federal University, Yekaterinburg, Russian Federation
Author Keywords long-term outcomes; nanomedicine; regression of atherosclerosis; safety; silica-gold nanoparticles
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Correspondence Address Kharlamov, A.N.; Department of Interventional Cardiovascular Biomedicine, De Haar Research Foundation, Handelsplein 15, Netherlands; email: drkharlamov@icloud.com
Publisher Future Medicine Ltd.
Language of Original Document English
Abbreviated Source Title Future Cardiol.
Source Scopus