The clotting tests and molecular markers in evaluating of coagulation alterations against the background of anti-thrombotic prevention by Dabigatran after large orthopedic operations / Antropova I.P., Reino E.V., Yushkov B.G. // Klinichescheskaya Laboratornaya Diagnostika. - 2017. - V. 2017-January, l. 1. - P. 25-30.

ISSN:
08692084
Type:
Article
Abstract:
The large orthopedic operations are associated with high risk of development of thrombosis of deep veins of lower extremities. Nowadays, new oral anticoagulants are widely applied for anti-thrombotic prevention. The coagulation alterations against the background of effect of Dabigatran, a direct inhibitor of thrombin were examined in 30 patients underwent endoprosthesis replacement of knee joint. The routine clotting indices, fibrinopeptid A, soluble fibrin-monomeric complexes, D-dimer. The samples of blood were selected before operation, after 30 minutes, andat 1st, 3d, 7th and 14th day after endoprosthesis replacement of knee joint. It is demonstrated that routine clotting tests and also detection of D-dimer and soluble fibrin-monomeric complexes provide no adequate evaluation of coagulation activity in patients underwent large orthopedic operation. The concentration of specific marker of fibrin formation of fibrinopeptid A continues to be increased no less than two weeks after endoprosthesis replacement of knee joint that testifies keeping hyper-coagulation and risk of thrombosis. The intake of Dabigatran etexilate in fixed dosage does not exclude development of thrombosis of deep veins of lower extremities that substantiates point of view concerning usefulness of individualization of anti-thrombotic prevention in case of application of new oral anti-coagulants.
Author keywords:
Clotting test; Coagulation; Dabigatran; Endoprosthesis replacement of knee joint; Molecular marker
Index keywords:
нет данных
DOI:
10.18821/0869-2084-2017-62-1-2
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018990699&doi=10.18821%2f0869-2084-2017-62-1-25-30&partnerID=40&md5=591047d8a56951637aaacea88e91bb48
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Link https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018990699&doi=10.18821%2f0869-2084-2017-62-1-25-30&partnerID=40&md5=591047d8a56951637aaacea88e91bb48
Affiliations Uralskii State Medical University of Minzdrav of Russia, Yekaterinburg, Russian Federation; Center of Specialized Types of Medical Care The V.D. Chaklin Uralskii Institute of Traumatology and Orthopedics, Yekaterinburg, Russian Federation; Institute of Immunology and Physiology, Uralskii Branch, Russian Academy of Sciences, Yekaterinburg, Russian Federation; First President of Russia B.N. Yeltsin Uralskii Federal University, Yekaterinburg, Russian Federation
Author Keywords Clotting test; Coagulation; Dabigatran; Endoprosthesis replacement of knee joint; Molecular marker
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Correspondence Address Antropova, I.P.email: aip.hemolab@mail.ru
Publisher Izdatel'stvo Meditsina
Language of Original Document Russian
Abbreviated Source Title Klin. Lab. Diagn.
Source Scopus