One-pot non-cyanide synthesis of 1-(pyridin-2-yl)isoquinoline-3-carbonitrile by reaction of 1-phenyl-2-{[}6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-yl]ethanone with 1,2-dehydrobenzene in the presence of isoamyl nitrite / Kopchuk D. S.,Nikonov I. L.,Krinochkin A. P.,Kovalev I. S.,Zyryanov G. V.,Rusinov V. L.,Chupakhin O. N. // RUSSIAN JOURNAL OF ORGANIC CHEMISTRY. - 2017. - V. 53, l. 6. - P. 959-961.

ISSN/EISSN:

1070-4280 / 1608-3393

Type:

Article

Abstract:

The reaction of 1-phenyl-2-{[}6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-yl]ethanone with 1,2-dehydrobenzene generated in situ from anthranilic acid and excess isoamyl nitrite afforded in one step 1-(pyridin-2-yl)-4-phenylisoquinoline-3-carbonitrile. This reaction may be regarded as a non-cyanide method for the synthesis of 3-cyanoisoquinolines.

Author keywords:

AS-TRIAZINE DERIVATIVES; 1,2,4-TRIAZINES; 5-CYANO-1,2,4-TRIAZINES; ISOQUINOLINES; SUBSTITUTION; COMPLEXES

DOI:

10.1134/S1070428017060264

Web of Science ID:

ISI:000406370300026

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUN
Publisher	MAIK NAUKA/INTERPERIODICA/SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013-1578 USA
Language	English
EISSN	1608-3393
Keywords-Plus	AS-TRIAZINE DERIVATIVES; 1,2,4-TRIAZINES; 5-CYANO-1,2,4-TRIAZINES; ISOQUINOLINES; SUBSTITUTION; COMPLEXES
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	gvzyryanov@gmail.com
Funding-Acknowledgement	Russian Science Foundation {[}16-43-02 020]; Council for Grants at the President of the Russian Federation {[}MK-644.2017.3]
Funding-Text	This study was performed under financial support by the Russian Science Foundation (project no. 16-43-02 020) and by the Council for Grants at the President of the Russian Federation (project no. MK-644.2017.3).
Number-of-Cited-References	21
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	1
Journal-ISO	Russ. J. Organ. Chem.
Doc-Delivery-Number	FB8DY