Nanostructured materials for magnetic biosensing / Kurlyandskaya Galina V.,Portnov Dmitriy S.,Beketov Igor V.,Larranaga Aitor,Safronov Alexander P.,Orue Inaki,Medvedev Anatoly I.,Chlenova Anna A.,Sanchez-Ilarduya Maria B.,Martinez-Amesti Ana,Svalov Andrey V. // BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. - 2017. - V. 1861, l. 6, SI. - P. 1494-1506.

ISSN/EISSN:

0304-4165 / 1872-8006

Type:

Review

Abstract:

Background: Magnetic nanoparticles (MNPs) are at the leading edge of the field of biomedical applications and magnetic biosensing. Methods: MNPs were fabricated by electrophysical methods of the laser target evaporation (LTE) and spark discharge with electrodynamic acceleration of plasma jumpers (SD). Synthesis of polyacrylamide hydrogel was done in the presence of Fe2O3 MNPs in different concentrations obtained by LTE. {[}FeNi/Ti](3)/Cu{[}Ti/FeNi](3)/Ti multilayers for giant magnetoimpedance (GMI) based sensitive elements were prepared by rf-sputtering for testing a biosensor prototype. Results: Iron oxide MNPs, ferrofluids, ferrofluids contacting with biological systems, synthetic ferrogels mimicking natural tissues - are the steps of the discussed in this work development of bionanomaterials. Thorough the structural and magnetic studies of a multilayered sensitive element, MNPs and ferrogels insure the complete characterization of biosensor prototype. The GMI responses were carefully evaluated in initial state and in the presence of ferrogel with known concentration of MNPs. SD MNPs had the smallest 5-8 nm size. This nanomaterial was characterized by large internal strains of the order of 25 x 10(-3), which can play an important role for the interaction with different biosystems. Conclusions: Iron oxide MNPs were fabricated by LTE and SD methods. SD MNPs had the smallest 5-8 nm size and large internal strains of the order of 25 x 10(-3). Designed GMI biosensor prototype allowed precise evaluation of the stray field of the MNPs present in the ferrogel by evaluating the systematic changes of the GMI in a 20-400 MHz frequency range. (C) 2016 Elsevier B.V. All rights reserved.

Author keywords:

Iron oxide nanoparticles; Laser target evaporation; Spark discharge; Ferrogels; Giant magnetoimpedance; Magnetic biosensing IRON-OXIDE NANOPOWDERS; SPARK DISCHARGE; NANOPARTICLES; GENERATION; SPECTRA; CELLS; FILMS; IONS

DOI:

10.1016/j.bbagen.2016.12.003

Web of Science ID:

ISI:000405056300004

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUN
Publisher	ELSEVIER SCIENCE BV
Address	PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Language	English
EISSN	1872-8006
Keywords-Plus	IRON-OXIDE NANOPOWDERS; SPARK DISCHARGE; NANOPARTICLES; GENERATION; SPECTRA; CELLS; FILMS; IONS
Research-Areas	Biochemistry \& Molecular Biology; Biophysics
Web-of-Science-Categories	Biochemistry \& Molecular Biology; Biophysics
Author-Email	galina@we.lc.ehu.es
ResearcherID-Numbers	Chlenova, Anna/O-9591-2017
ORCID-Numbers	Chlenova, Anna/0000-0001-9562-7807 Svalov, Andrey/0000-0002-4549-8282
Funding-Acknowledgement	Spanish MEC project {[}MAT2014-55049-C2-1-R]; RF project {[}0389-2014-0002]
Funding-Text	This work was supported by the Spanish MEC project MAT2014-55049-C2-1-R and RF project No 0389-2014-0002. We thank Iu. P. Novoselova, Dr. T. P. Denisova, Dr. R. Andrade, Dr. A. M. Murzakaev, Prof. F.A. Blyahman, Prof. L.S. Litvinova, Prof. I.A. Khlusov and A.A. Svalova for special support. Selected measurements were done at SGIKER UPV-EHU services.
Number-of-Cited-References	49
Usage-Count-Last-180-days	14
Usage-Count-Since-2013	14
Journal-ISO	Biochim. Biophys. Acta-Gen. Subj.
Doc-Delivery-Number	EZ9NE