Silicon-zinc-glycerol hydrogel, a potential immunotropic agent for topical application / Khonina Tat'yana G.,Ivanenko Maria V.,Chupakhin Oleg N.,Safronov Alexander P.,Bogdanova Ekaterina A.,Karabanalov Maxim S.,Permikin Vasily V.,Larionov Leonid P.,Drozdova Lyudmila I. // EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. - 2017. - V. 107, l. . - P. 197-202.

ISSN/EISSN:

0928-0987 / 1879-0720

Type:

Article

Abstract:

Nanoparticles synthesized using sol-gel method are promising agents for biomedical applications, in particular for the therapy and diagnosis of various diseases. Using silicon and zinc glycerolates as biocompatible precursors we synthesized by the sol-gel method a new bioactive silicon-zinc-containing glycerohydrogel combining the positive pharmacological properties of the precursors. In the present work the structural features of silicon-zinccontaining glycerohydrogel and its immunotropic properties were studied. The advanced physical methods, including XRD, TEM, dynamic and electrophoretic light scattering, were used for studying the structural features of the gel. Hydrolysis of zinc monoglycerolate was investigated under gelation conditions. Evaluation of the efficiency of silicon-zinc-containing glycerohydrogel in providing immune functions was carried out using a model of the complicated wound process behind immunosuppression induced by hydrocortisone administration in the Wistar rats. It has been shown that zinc monoglycerolate exists in the state of amorphous nanoparticles in the cells of 3D-network formed due to incomplete hydrolysis of silicon glycerolates and subsequent silanol condensation. Zinc monoglycerolate is not hydrolyzed and does not enter 3D-network of the gel with the formation of Zn-O-Si groups, but it forms a separate phase. Immunotropic action of silicon-zinc-containing glycerohydrogel was revealed by the histology and immunohistochemistry methods. Amorphous nanoparticles of zinc monoglycerolate, water-soluble silicon glycerolates, and products of their hydrolytic transformations, which are present in a aqueous-glycerol medium, are in the first place responsible for the pharmacological activity of hydrogel. The results obtained allow us to consider silicon-zinc-containing glycerohydrogel as a promising immunotropic agent for topical application.

Author keywords:

Silicon and zinc glycerolates; Biocompatible precursors; Sol-gel synthesis; Silicon-zinc-glycerol hydrogel; Hydrolysis of zinc monoglycerolate; Immunotropic activity SOL-GEL SYNTHESIS; MODIFIED SILANES; CANCER; PRECURSORS; MONOLITHS; NANOMATERIALS; LIPOSOMES; DELIVERY; PEPTIDE

DOI:

10.1016/j.ejps.2017.07.012

Web of Science ID:

ISI:000407836700019

Соавторы в МНС:

Другие поля

Поле	Значение
Month	SEP 30
Publisher	ELSEVIER SCIENCE BV
Address	PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Language	English
EISSN	1879-0720
Keywords-Plus	SOL-GEL SYNTHESIS; MODIFIED SILANES; CANCER; PRECURSORS; MONOLITHS; NANOMATERIALS; LIPOSOMES; DELIVERY; PEPTIDE
Research-Areas	Pharmacology \& Pharmacy
Web-of-Science-Categories	Pharmacology \& Pharmacy
Author-Email	khonina@ios.uran.ru
ORCID-Numbers	Karabanalov, Maxim/0000-0001-6619-2816
Funding-Acknowledgement	Russian Foundation for Basic Research {[}15-03-01770 A]
Funding-Text	This work was supported by the Russian Foundation for Basic Research (project No. 15-03-01770 A).
Number-of-Cited-References	38
Usage-Count-Last-180-days	5
Usage-Count-Since-2013	5
Journal-ISO	Eur. J. Pharm. Sci.
Doc-Delivery-Number	FD9IT