Synthesis and biological evaluation of novel 5-aryl-4-(5-nitrofuran-2yl)-pyrimidines as potential anti-bacterial agents / Verbitskiy Egor V.,Baskakova Svetlana A.,Gerasimova Natal'ya A.,Evstigneeva Natal'ya P.,Zil'berberg Natal'ya V.,Kungurov Nikolay V.,Kravchenko Marionella A.,Skornyakov Sergey N.,Pervova Marina G.,Rusinov Gennady L.,Chupakhin Oleg N.,Charushin Valery N. // BIOORGANIC \& MEDICINAL CHEMISTRY LETTERS. - 2017. - V. 27, l. 13. - P. 3003-3006.

ISSN/EISSN:

0960-894X / 1464-3405

Type:

Article

Abstract:

A facile two-step synthetic approach to fluorinated and non-fluorinated 5-aryl-4-(5-nitrofuran-2-yl)-pyrimidines from readily available 5-bromo-4-(furan-2-yl)-pyrimidine has been developed. All synthesized compounds were screened in vitro for their antibacterial activities against twelve various bacterial strains. It is demonstrated that some of these compounds exhibited significant antibacterial activities against strains Neisseria gonorrhoeae and Staphylococcus aureus, comparable and even higher with that commercial drug Spectinomycin. (C) 2017 Elsevier Ltd. All rights reserved.

Author keywords:

Pyrimidine; Nitrofuran; Antigonorrheal; Antimycobacterial; Nucleophilic aromatic substitution of hydrogen SUBSTITUTED PYRIMIDINES; ANTITUBERCULAR ACTIVITY

DOI:

10.1016/j.bmcl.2017.05.013

Web of Science ID:

ISI:000402470600031

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUL 1
Publisher	PERGAMON-ELSEVIER SCIENCE LTD
Address	THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Language	English
EISSN	1464-3405
Keywords-Plus	SUBSTITUTED PYRIMIDINES; ANTITUBERCULAR ACTIVITY
Research-Areas	Pharmacology \& Pharmacy; Chemistry
Web-of-Science-Categories	Chemistry, Medicinal; Chemistry, Organic
Author-Email	Verbitsky@ios.uran.ru
Funding-Acknowledgement	Russian Science Foundation {[}15-13-00077]
Funding-Text	The research was financially supported by the Russian Science Foundation (Project No. 15-13-00077).
Number-of-Cited-References	17
Usage-Count-Last-180-days	4
Usage-Count-Since-2013	4
Journal-ISO	Bioorg. Med. Chem. Lett.
Doc-Delivery-Number	EW4KO