A paradoxical response of the rat organism to long-term inhalation of silica containing submicron (predominantly nanoscale) particles of a collected industrial aerosol at realistic exposure levels / Sutunkova Marina P.,Solovyeva Svetlana N.,Katsnelson Boris A.,Gurvich Vladimir B.,Privalova Larisa I.,Minigalieva Ilzira A.,Slyshkina Tatyana V.,Valamina Irene E.,Makeyev Oleg H.,Shur Vladimir Ya.,Zubarev Ilya V.,Kuznetsov Dmitry K.,Shishkina Ekaterina V. // TOXICOLOGY. - 2017. - V. 384, l. . - P. 59

ISSN/EISSN:

0300-483X / нет данных

Type:

Article

Abstract:

While engineered SiO(2)nanoparticle toxicity is being widely investigated, mostly on cell lines or in acute animal experiments, the practical importance of as well as the theoretical interest in industrial condensation aerosols with a high SiO(2)particle content seems to be neglected. That is why, to the best of our knowledge, long-term inhalation exposure to nano-SiO(2)has not been undertaken in experimental nanotoxicology studies. To correct this data gap, female white rats were exposed for 3 or 6 months 5 times a week, 4 h a day to an aerosol containing predominantly submicron (nanoscale included) particles of amorphous silica at an exposure concentration of 2.6 +/- 06 or 10.6 +/- 2.1 mg/m(3). This material had been collected from the flue-gas ducts of electric ore smelting furnaces that were producing elemental silicon, subsequently sieved through a < 2 mu m screen and redispersed to feed a computerized ``nose only{''} inhalation system. In an auxiliary experiment using a single-shot intratracheal instillation of these particles, it was shown that they induced a pulmonary cell response comparable with that of a highly cytotoxic and fibrogenic quartz powder, namely DQ12. However, in longterm inhalation tests, the aerosol studied proved to be of very low systemic toxicity and negligible pulmonary fibrogenicity. This paradox may be explained by a low SiO(2)retention in the lungs and other organs due to the relatively high solubility of these nanoparticles. nasal penetration of nanoparticles into the brain as well as their genotoxic action were found in the same experiment, results that make one give a cautious overall assessment of this aerosol as an occupational or environmental hazard.

Author keywords:

Nano-silica containing industrial aerosol; Long-term inhalation exposure; Toxicity; Fibrogenicity; Toxicokinetics CENTRAL-NERVOUS-SYSTEM; IN-VIVO; OXIDE NANOPARTICLES; OXIDATIVE STRESS; INTRATRACHEAL INSTILLATION; DIFFERENT CYTOTOXICITY; CELL-LINE; BIOPROTECTORS; TOXICITY; TRANSLOCATION

DOI:

10.1016/j.tox.2017.04.010

Web of Science ID:

ISI:000402357200007

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUN 1
Publisher	ELSEVIER IRELAND LTD
Address	ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
Language	English
Keywords-Plus	CENTRAL-NERVOUS-SYSTEM; IN-VIVO; OXIDE NANOPARTICLES; OXIDATIVE STRESS; INTRATRACHEAL INSTILLATION; DIFFERENT CYTOTOXICITY; CELL-LINE; BIOPROTECTORS; TOXICITY; TRANSLOCATION
Research-Areas	Pharmacology \& Pharmacy; Toxicology
Web-of-Science-Categories	Pharmacology \& Pharmacy; Toxicology
Author-Email	bkaznelson@etel.ru
ResearcherID-Numbers	Shur, Vladimir/J-9078-2015
Number-of-Cited-References	43
Usage-Count-Last-180-days	13
Usage-Count-Since-2013	13
Journal-ISO	Toxicology
Doc-Delivery-Number	EW2WR