Effects of cellular electromechanical coupling on functional heterogeneity in a one-dimensional tissue model of the myocardium / Khokhlova Anastasia,Balakina-Vikulova Nathalie,Katsnelson Leonid,Solovyova Olga // COMPUTERS IN BIOLOGY AND MEDICINE. - 2017. - V. 84, l. . - P. 147-155.

ISSN/EISSN:

0010-4825 / 1879-0534

Type:

Article

Abstract:

Based on the experimental evidence, we developed a one-dimensional (1D) model of heterogeneous myocardial tissue consisting of in-series connected cardiomyocytes from distant transmural regions using mathematical models of subendocardial and subepicardial cells. The regional deformation patterns produced by our 1D model are consistent with the transmural regional strain patterns obtained experimentally in the normal heart in vivo. The modelling results suggest that the mechanical load may essentially affect the transmural gradients in the electrical and mechanical properties of interacting myocytes within a tissue, thereby regulating global myocardial output.

Author keywords:

Electromechanical coupling; Cardiac heterogeneity; Cardiac mechanics ELECTRICAL HETEROGENEITY; TRANSMURAL DISPERSION; VENTRICULAR ANATOMY; HEART; MYOCYTES; CELLS; ARRANGEMENT; ARRHYTHMIAS; PROPAGATION; CONTRACTION

DOI:

10.1016/j.compbiomed.2017.03.0

Web of Science ID:

ISI:000401377700015

Соавторы в МНС:

Другие поля

Поле	Значение
Month	MAY 1
Publisher	PERGAMON-ELSEVIER SCIENCE LTD
Address	THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Language	English
EISSN	1879-0534
Keywords-Plus	ELECTRICAL HETEROGENEITY; TRANSMURAL DISPERSION; VENTRICULAR ANATOMY; HEART; MYOCYTES; CELLS; ARRANGEMENT; ARRHYTHMIAS; PROPAGATION; CONTRACTION
Research-Areas	Life Sciences \& Biomedicine - Other Topics; Computer Science; Engineering; Mathematical \& Computational Biology
Web-of-Science-Categories	Biology; Computer Science, Interdisciplinary Applications; Engineering, Biomedical; Mathematical \& Computational Biology
Author-Email	a.khokhlova@iip.uran.ru
ResearcherID-Numbers	Balakina-Vikulova, Nathalie/D-9833-2015 Solovyova, Olga/T-8232-2017
ORCID-Numbers	Balakina-Vikulova, Nathalie/0000-0003-1316-4437
Funding-Acknowledgement	Russian Science Foundation {[}14-35-00005]
Funding-Text	This work was supported by the Russian Science Foundation (\#14-35-00005). The authors thank Dr. Oleg Lookin for providing the experimental data on the dependence of passive tension on papillary muscle strain (Fig. 3B).
Number-of-Cited-References	42
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	1
Journal-ISO	Comput. Biol. Med.
Doc-Delivery-Number	EU9RQ