Zebrafish models in neuropsychopharmacology and CNS drug discovery / Khan Kanza M.,Collier Adam D.,Meshalkina Darya A.,Kysil Elana V.,Khatsko Sergey L.,Kolesnikova Tatyana,Morzherin Yury Yu,Warnick Jason E.,Kalueff Allan V.,Echevarria David J. // BRITISH JOURNAL OF PHARMACOLOGY. - 2017. - V. 174, l. 13. - P. 1925-1944.

ISSN/EISSN:

0007-1188 / 1476-5381

Type:

Review

Abstract:

Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized as a powerful animal model in neuropharmacology research and in vivo drug screening. Collectively, this makes zebrafish a useful tool for drug discovery and the identification of disordered molecular pathways. Here, we discuss zebrafish models of selected human neuropsychiatric disorders and drug-induced phenotypes. As well as covering a broad range of brain disorders (from anxiety and psychoses to neurodegeneration), we also summarize recent developments in zebrafish genetics and small molecule screening, which markedly enhance the disease modelling and the discovery of novel drug targets.

Author keywords:

AMYOTROPHIC-LATERAL-SCLEROSIS; CONDITIONED PLACE PREFERENCE; MEDIAL PREFRONTAL CORTEX; COMPUTER ANIMATED FISH; C-FOS EXPRESSION; DANIO-RERIO; ADULT ZEBRAFISH; ALZHEIMERS-DISEASE; LARVAL ZEBRAFISH; ANTIPSYCHOTIC-DRUGS

DOI:

10.1111/bph.13754

Web of Science ID:

ISI:000403299900005

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	JUL
Publisher	WILEY
Address	111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Language	English
EISSN	1476-5381
Keywords-Plus	AMYOTROPHIC-LATERAL-SCLEROSIS; CONDITIONED PLACE PREFERENCE; MEDIAL PREFRONTAL CORTEX; COMPUTER ANIMATED FISH; C-FOS EXPRESSION; DANIO-RERIO; ADULT ZEBRAFISH; ALZHEIMERS-DISEASE; LARVAL ZEBRAFISH; ANTIPSYCHOTIC-DRUGS
Research-Areas	Pharmacology \& Pharmacy
Web-of-Science-Categories	Pharmacology \& Pharmacy
Author-Email	avkalueff@gmail.com David.echevarria@usm.edu
ResearcherID-Numbers	Khatsko, Sergey/E-3215-2017 Kolesnikova, Tatiana/E-3292-2017
ORCID-Numbers	Khatsko, Sergey/0000-0001-5921-6680 Kolesnikova, Tatiana/0000-0002-5561-8583
Funding-Acknowledgement	St. Petersburg State University; Ural Federal University; Guangdong Ocean University; Russian Foundation for Basic Research (RFBR) {[}16-04-00851]
Funding-Text	The study was coordinated through the International Zebrafish Neuroscience Research Consortium (ZNRC), and this collaboration was funded by St. Petersburg State University, Ural Federal University and Guangdong Ocean University. A.V.K. is the Chair of ZNRC, and his research is supported by the Russian Foundation for Basic Research (RFBR) grant 16-04-00851.
Number-of-Cited-References	268
Usage-Count-Last-180-days	4
Usage-Count-Since-2013	4
Journal-ISO	Br. J. Pharmacol.
Doc-Delivery-Number	EX5RO