Synthesis, characterization and in vivo evaluation of biocompatible ferrogels / Lopez-Lopez M. T.,Rodriguez I. A.,Rodriguez-Arco L.,Carriel V.,Bonhome-Espinosa A. B.,Campos F.,Zubarev A.,Duran J. D. G. // JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS. - 2017. - V. 431, l. . - P. 110-114.

ISSN/EISSN:

0304-8853 / 1873-4766

Type:

Article; Proceedings Paper

Abstract:

A hydrogel is a 3-D network of polymer chains in which water is the dispersion medium. Hydrogels have found extensive applications in the biomedical field due to their resemblance to living tissues. Furthermore, hydrogels can be endowed with exceptional properties by addition of synthetic materials. For example, magnetic field-sensitive gels, called ferrogels, are obtained by embedding magnetic particles in the polymer network. Novel living tissues with unique magnetic field-sensitive properties were recently prepared by 3-D cell culture in biocompatible ferrogels. This paper critically reviews the most recent progress and perspectives in their synthesis, characterization and biocompatibility evaluation. Optimization of ferrogels for this novel application requires low-density, strongly magnetic, multi-domain particles. Interestingly, the rheological properties of the resulting ferrogels in the absence of field were largely enhanced with respect to nonmagnetic hydrogels, which can only be explained by the additional cross-linking imparted by the embedded magnetic particles. Remarkably, rheological measurements under an applied magnetic field demonstrated that ferrogels presented reversibly tunable mechanical properties, which constitutes a unique advantage with respect to nonmagnetic hydrogels. In vivo evaluation of ferrogels showed good biocompatibility, with only some local inflammatory response, and no particle migration or damage to distant organs. (C) 2016 Elsevier B.V. All rights reserved.

Author keywords:

Ferrogel; Polymer; Magnetic particle; Rheology; Magnetorheology; In vivo NANOPARTICLES; SCAFFOLDS

DOI:

10.1016/j.jmmm.2016.08.053

Web of Science ID:

ISI:000399598600028

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	JUN 1
Note	14th International Conference on Magnetic Fluids (ICMF), Ekaterinburg, RUSSIA, JUL 04-08, 2016
Publisher	ELSEVIER SCIENCE BV
Address	PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Language	English
EISSN	1873-4766
Keywords-Plus	NANOPARTICLES; SCAFFOLDS
Research-Areas	Materials Science; Physics
Web-of-Science-Categories	Materials Science, Multidisciplinary; Physics, Condensed Matter
Author-Email	modesto@ugr.es
ResearcherID-Numbers	Lopez-Lopez, Modesto T/K-7327-2012
ORCID-Numbers	Lopez-Lopez, Modesto T/0000-0002-9068-7795
Funding-Acknowledgement	MINECO, Spain {[}FIS2013-41821-R]; ERDF, European Union - Spanish MINECO(Instituto CarlosIII) {[}FISPI14-1343]; ERDF of the European Union; Russian Scientific Foundation {[}14-19-00989]
Funding-Text	Financial support: project FIS2013-41821-R(MINECO, Spain; co-funded by ERDF, European Union); project FISPI14-1343 funded by the Spanish MINECO(Instituto CarlosIII), co-funded by the ERDF of the European Union; AZ also acknowledges the Russian Scientific Foundation, project 14-19-00989.
Number-of-Cited-References	16
Usage-Count-Last-180-days	11
Usage-Count-Since-2013	12
Journal-ISO	J. Magn. Magn. Mater.
Doc-Delivery-Number	ES5QV