Effect of particle concentration on the microstructural and macromechanical properties of biocompatible magnetic hydrogels / Bonhome-Espinosa A. B.,Campos F.,Rodriguez I. A.,Carriel V.,Marins J. A.,Zubarev A.,Duran J. D. G.,Lopez-Lopez M. T. // SOFT MATTER. - 2017. - V. 13, l. 16. - P. 2928-2941.

ISSN/EISSN:

1744-683X / 1744-6848

Type:

Article

Abstract:

We analyze the effect of nanoparticle concentration on the physical properties of magnetic hydrogels consisting of polymer networks of the human fibrin biopolymer with embedded magnetic particles, swollen by a water-based solution. We prepared these magnetic hydrogels by polymerization of mixtures consisting mainly of human plasma and magnetic nanoparticles with OH- functionalization. Microscopic observations revealed that magnetic hydrogels presented some cluster-like knots that were connected by several fibrin threads. By contrast, nonmagnetic hydrogels presented a homogeneous net-like structure with only individual connections between pairs of fibers. The rheological analysis demonstrated that the rigidity modulus, as well as the viscoelastic moduli, increased quadratically with nanoparticle content following a square-like function. Furthermore, we found that time for gel point was shorter in the presence of magnetic nanoparticles. Thus, we can conclude that nanoparticles favor the cross-linking process, serving as nucleation sites for the attachment of the fibrin polymer. Attraction between the positive groups of the fibrinogen, from which the fibrin is polymerized, and the negative OH- groups of the magnetic particle surface qualitatively justifies the positive role of the nanoparticles in the enhancement of the mechanical properties of the magnetic hydrogels. Indeed, we developed a theoretical model that semiquantitatively explains the experimental results by assuming the indirect attraction of the fibrinogen through the attached nanoparticles. Due to this attraction the monomers condense into nuclei of the dense phase and by the end of the polymerization process the nuclei (knots) of the dense phase cross-link the fibrin threads, which enhances their mechanical properties.

Author keywords:

TRANSFORM MECHANICAL SPECTROSCOPY; TISSUE-ENGINEERING APPLICATIONS; CROSS-LINKING POLYMER; GEL POINT; LINEAR VISCOELASTICITY; HUMAN FIBRINOGEN; SCAFFOLDS; NANOPARTICLES; GELATION; MUCOSA

DOI:

10.1039/c7sm00388a

Web of Science ID:

ISI:000399877400004

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	APR 28
Publisher	ROYAL SOC CHEMISTRY
Address	THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Language	English
EISSN	1744-6848
Keywords-Plus	TRANSFORM MECHANICAL SPECTROSCOPY; TISSUE-ENGINEERING APPLICATIONS; CROSS-LINKING POLYMER; GEL POINT; LINEAR VISCOELASTICITY; HUMAN FIBRINOGEN; SCAFFOLDS; NANOPARTICLES; GELATION; MUCOSA
Research-Areas	Chemistry; Materials Science; Physics; Polymer Science
Web-of-Science-Categories	Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Multidisciplinary; Polymer Science
Author-Email	modesto@ugr.es
ResearcherID-Numbers	Lopez-Lopez, Modesto T/K-7327-2012
ORCID-Numbers	Lopez-Lopez, Modesto T/0000-0002-9068-7795 Carriel, Victor/0000-0002-8114-5644
Funding-Acknowledgement	Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica, Ministerio de Economia y Competitividad, Spain {[}FIS2013-41821-R]; ERDF, European Union {[}FIS2013-41821-R]; Spanish Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica, from the National Ministry of Economy and Competitiveness - Instituto de Salud Carlos III {[}FIS PI14-1343]; Fondo Europeo de Desarrollo Regional - FEDER-, European Union {[}FIS PI14-1343]; CNPq {[}203100/2014-0]; Russian Fund for Basic Research {[}16-58-12003]; Program of Russian Federation Ministry of Science and Education {[}3.1438.2017/PCh]
Funding-Text	This study was supported by project FIS2013-41821-R (Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica, Ministerio de Economia y Competitividad, Spain, co-funded by ERDF, European Union) and by grant FIS PI14-1343 (Spanish Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica, from the National Ministry of Economy and Competitiveness - Instituto de Salud Carlos III; co-financed by Fondo Europeo de Desarrollo Regional - FEDER-, European Union). J. M. A. acknowledges financial support from CNPq through its postdoctoral fellowship program (Ref. No. 203100/2014-0). A. Z. is also grateful to the Russian Fund for Basic Research, 16-58-12003, the Program of Russian Federation Ministry of Science and Education, project 3.1438.2017/PCh. Dr Laura Rodriguez-Arco is acknowledged for helpful discussion. This work is part of the PhD thesis of A. B. B.-E.
Number-of-Cited-References	75
Usage-Count-Last-180-days	8
Usage-Count-Since-2013	9
Journal-ISO	Soft Matter
Doc-Delivery-Number	ES9KX