Synthesis of Pyridone Derivatives from 7-Hydroxy-7-polyfluoroalkylhexahydroimidazo{[}1,2-a] pyridin-5-ones / Goryaeva Marina V.,Burgart Yanina V.,Kudyakova Yulia S.,Ezhikova Marina A.,Kodess Mikhail I.,Saloutin Victor I. // EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - 2017. - V. , l. 27. - P. 3986-3991.

ISSN/EISSN:

1434-193X / 1099-0690

Type:

Article

Abstract:

The synthesis of 1-(2-aminoethyl)-6-alkyl-4-poly-fluoroalkylpyridin- 2-ones based on the acidic cleavage of 7-hydroxy- 7-polyfluoroalkylhexahydroimidazo{[}1,2-a] pyridin-5-ones is reported. Depending on the reaction conditions, the pyridones can be obtained as bases, salts, acetamides, or the products of intramolecular cyclization, dihydroimidazopyridines. High tuberculostatic activity was observed for some of the synthesized compounds.

Author keywords:

Polyfluoroalkylated compounds; Nitrogen heterocycles; Fused-ring systems; Dehydration; 2-Piridones; Recyclization; Imidazo{[}1,2-a]pyridines MEDICINAL CHEMISTRY; FLUORINE; 2-PYRIDONES; PERAMPANEL

DOI:

10.1002/ejoc.201700683

Web of Science ID:

ISI:000405933300013

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JUL 25
Publisher	WILEY-V C H VERLAG GMBH
Address	POSTFACH 101161, 69451 WEINHEIM, GERMANY
Language	English
EISSN	1099-0690
Keywords-Plus	MEDICINAL CHEMISTRY; FLUORINE; 2-PYRIDONES; PERAMPANEL
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	ya.burgart@yandex.ru
ResearcherID-Numbers	Burgart, Yanina/T-8025-2017
ORCID-Numbers	Burgart, Yanina/0000-0001-6061-2410
Funding-Acknowledgement	Ural Branch of the Russian Academy of Sciences {[}15-21-3-5]
Funding-Text	This research was financially supported by the Ural Branch of the Russian Academy of Sciences (grant no. 15-21-3-5). The authors gratefully acknowledge Dr. M. A. Kravchenko for assistance in determining the tuberculostatic activity of the compounds obtained.
Number-of-Cited-References	27
Usage-Count-Last-180-days	3
Usage-Count-Since-2013	3
Journal-ISO	Eur. J. Org. Chem.
Doc-Delivery-Number	FB1WB