Identification and interconversion of isomeric 4,5-functionalized 1,2,3-thiadiazoles and 1,2,3-triazoles in conditions of electrospray ionization / Mazur D. M.,Zimens M. E.,Bakulev V. A.,Lebedev A. T. // JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. - 2017. - V. 145, l. . - P. 315-321.

ISSN/EISSN:

0731-7085 / 1873-264X

Type:

Article

Abstract:

1,2,3-Triazoles and 1,2,3-thiadiazoles have been receiving permanent interest due to their exciting chemical reactivity and interesting biological properties including antibacterial, anticancer and antiviral activities. There are four compounds bearing 1H-1,2,3-triazole core in clinical studies which may appear in the market of drugs in nearest future. Definitely reliable methods of their identification and quantification should be developed by that time. Mass spectrometry showed itself as the most reliable method of analysis when dealing with trace levels of organic compounds in the mixtures and in the most complex matrices, including biological ones. In the present study tandem mass spectrometry was used to study fragmentation pathways of protonated and deprotonated molecules of isomeric 4,5-functionalized 1,2,3-thiadiazoles and 1,2,3-triazoles in conditions of electrospray ionization (ESI). A group of marker ions allowing differentiation between the targeted isomeric compounds was established. Besides, interconversion of these isomers into one another was studied in the gas phase in conditions mimicking these processes in solution. (C) 2017 Elsevier B.V. All rights reserved.

Author keywords:

Mass spectrometry; Electrospray ionization; 1,2,3-thiadiazoles; 1,2,3-triazoles; Isomer identification MASS-SPECTROMETRY; DIAZO-COMPOUNDS; GAS-PHASE; DIFFERENTIATION; SPECTRA; REARRANGEMENT; IMPACT; ACIDS

DOI:

10.1016/j.jpba.2017.06.064

Web of Science ID:

ISI:000410872200039

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	OCT 25
Publisher	ELSEVIER SCIENCE BV
Address	PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Language	English
EISSN	1873-264X
Keywords-Plus	MASS-SPECTROMETRY; DIAZO-COMPOUNDS; GAS-PHASE; DIFFERENTIATION; SPECTRA; REARRANGEMENT; IMPACT; ACIDS
Research-Areas	Chemistry; Pharmacology \& Pharmacy
Web-of-Science-Categories	Chemistry, Analytical; Pharmacology \& Pharmacy
Author-Email	a.lebedev@org.chem.msu.ru
Number-of-Cited-References	22
Usage-Count-Last-180-days	2
Usage-Count-Since-2013	2
Journal-ISO	J. Pharm. Biomed. Anal.
Doc-Delivery-Number	FH1AQ