Metal-free C-H functionalization of 2H-imidazole 1-oxides with pyrrolyl fragments in the design of novel azaheterocyclic ensembles / Varaksin Mikhail,Moseev Timofey,Chupakhin Oleg,Charushin Valery,Trofimov Boris // ORGANIC \& BIOMOLECULAR CHEMISTRY. - 2017. - V. 15, l. 39. - P. 8280-8284.

ISSN/EISSN:

1477-0520 / 1477-0539

Type:

Article

Abstract:

The methodology of direct C(sp(2))-H functionalization has for the first time been applied as an efficient and advanced approach to carry out C-H/C-H coupling of 2H-imidazole 1-oxides and pyrroles. The atom-economical method used does not require either any auxiliary group in the starting substrates, or catalysis by transition metals. As a result, a number of novel 1H-pyrrol-2-yl-2H-imidazoles, that are particularly of interest in the design of bioactive molecules, have been prepared under mild conditions and in good to excellent yields.

Author keywords:

DRUG TARGETS; N-OXIDES; SUBSTITUTION; DERIVATIVES; OPINION

DOI:

10.1039/c7ob01999h

Web of Science ID:

ISI:000412827300004

Соавторы в МНС:

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Другие поля

Поле	Значение
Month	OCT 21
Publisher	ROYAL SOC CHEMISTRY
Address	THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Language	English
EISSN	1477-0539
Keywords-Plus	DRUG TARGETS; N-OXIDES; SUBSTITUTION; DERIVATIVES; OPINION
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	chupakhin@ios.uran.ru
ORCID-Numbers	Moseev, Timofey/0000-0003-3341-5838 Varaksin, Mikhail/0000-0002-7997-3686
Funding-Acknowledgement	Russian Science Foundation {[}14-13-01177]; Council on Grants of the President of Russia for Leading Scientific Schools {[}NSh-8922.2016.3]
Funding-Text	The research was financially supported by the Russian Science Foundation (Project No. 14-13-01177, synthesis of pyrrolyl imidazoles) and the Council on Grants of the President of Russia for Leading Scientific Schools (Project NSh-8922.2016.3, X-Ray analysis).
Number-of-Cited-References	48
Usage-Count-Last-180-days	3
Usage-Count-Since-2013	3
Journal-ISO	Org. Biomol. Chem.
Doc-Delivery-Number	FJ5XO