Synthesis of tetrazole containing 1,2,3-thiadiazole derivatives via U-4CR and their anti-TMV activity / Wang S.-X., Fang Z., Fan Z.-J., Wang D., Li Y.-D., Ji X.-T., Hua X.-W., Huang Y., Kalinina T.A., Bakulev V.A., Morzherin Y.Y. // Chinese Chemical Letters. - 2013. - V. 24, l. 10. - P. 889-892.

ISSN:
10018417
Type:
Article
Abstract:
A series of novel tetrazole containing 1,2,3-thiadiazole derivatives were designed and synthesized via Ugi reaction. Their structures were confirmed by melting points, IR, 1H NMR, and HRMS (ESI). Preliminary bioassay indicated that most target compounds exhibited very good direct anti-TMV activity at 100 μg/mL, which was equal to or higher than that of ribavirin. Among them, compounds 4b, 4c and 4i also showed equivalent protection effect to ribavirin in vivo at 100 μg/mL. © 2013 Zhi-Jin Fan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Author keywords:
1,2,3-Thiadiazole; Anti-TMV activity; Tetrazole; Ugi reaction
Index keywords:
нет данных
DOI:
10.1016/j.cclet.2013.05.026
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-84883742792&doi=10.1016%2fj.cclet.2013.05.026&partnerID=40&md5=cf86e80ae46ae090b29beab0da0a514a
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Link https://www.scopus.com/inward/record.uri?eid=2-s2.0-84883742792&doi=10.1016%2fj.cclet.2013.05.026&partnerID=40&md5=cf86e80ae46ae090b29beab0da0a514a
Affiliations School of Basic Sciences, Jining Medical University, Jining 272067, China; State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China; Department of Plant Pathology, Sichuan Agricultural University, Chengdu 611130, China; Ural Federal University Named after the First President of Russia B.N. Yeltsin, Yeltsin UrFU, 620002 Ekaterinburg, Russian Federation
Author Keywords 1,2,3-Thiadiazole; Anti-TMV activity; Tetrazole; Ugi reaction
Funding Details 10JCZDJC17500, NSF, National Science Foundation
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Correspondence Address Fan, Z.-J.; State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China; email: fanzj@nankai.edu.cn
CODEN CCLEE
Language of Original Document English
Abbreviated Source Title Chin. Chem. Lett.
Source Scopus