Synthesis of the [2H,15N]-labeled antiviral drug "triazavirine" / Shestakova T.S., Khalymbadzha I.A., Deev S.L., Eltsov O.S., Rusinov V.L., Shenkarev Z.O., Arseniev A.S., Chupakhin O.N. // Russian Chemical Bulletin. - 2011. - V. 60, l. 4. - P. 729-732.

ISSN:

10665285

Type:

Article

Abstract:

Selective methods for the incorporation of stable isotopes 15N and 2H into the structure of antiviral medicine " triazavirine" 1 were developed. The synthesized isotopically modified "triazavirine" 1- 2 H 3, 15 N 3 contained the labeled atoms in both the azole and the azine rings. 13C and 15N NMR spectra of the isotope-containing sample 1- 2 H 3, 15 N 3 were thoroughly analyzed. © 2011 Springer-Verlag.

Author keywords:

[2H,15N]-labeled "triazavirine"; azocoupling; diazonium salt; NMR spectra

Index keywords:

нет данных

DOI:

10.1007/s11172-011-0113-z

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https://www.scopus.com/inward/record.uri?eid=2-s2.0-83455171647&doi=10.1007%2fs11172-011-0113-z&partnerID=40&md5=62dc0c3d660b194a51054aa05d4a8af9

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Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-83455171647&doi=10.1007%2fs11172-011-0113-z&partnerID=40&md5=62dc0c3d660b194a51054aa05d4a8af9
Affiliations	Ural Federal University, 19 ul. Mira, Ekaterinburg 620002, Russian Federation; I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, 22 ul. S. Kovalevskoi, Ekaterinburg 620041, Russian Federation; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 ul. Miklukho-Maklaya, Moscow 117997, Russian Federation
Author Keywords	[2H,15N]-labeled "triazavirine"; azocoupling; diazonium salt; NMR spectra
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Correspondence Address	Deev, S.L.; Ural Federal University, 19 ul. Mira, Ekaterinburg 620002, Russian Federation; email: deevsl@yandex.ru
Language of Original Document	English
Abbreviated Source Title	Russ. Chem. Bull.
Source	Scopus