Plasmonics for treatment of atherosclerosis: Results of NANOM-FIM trial / Kharlamov A.N., Tyurnina A.E., Veselova V.S., Novoselova O.S., Filatova A.S., Kovtun O.P., Shur V.Y., Gabinsky J.L. // Journal of Nanomedicine and Nanotechnology. - 2013. - V. 4, l. 1.

ISSN:
21577439
Type:
Article
Abstract:
Background: Atheroregression becomes an attractive target for cardiovascular treatment. Some clinical trials have demonstrated that intensive therapy with rosuvastatin or recombinant ApoA-I Milano can partially reduce the total atheroma volume (TAV) up to 6.38 mm3 or 14.1 mm3 respectively. Our previous bench studies of selected nanotechnologies documented TAV reduction up to unprecedented 79.4 mm3. Methods: The completed observational three arms (n=180) first-in-man trial (the NANOM FIM trial) assessed (NCT01270139) the safety and feasibility of two delivery techniques for nanoparticles (NP), and plasmonic photothermal therapy (PPTT). Patients were assigned to receive either (1) nano-intervention with delivery of silica-gold NP in bioengineered on-artery patch (n=60), or (2) nano-intervention with delivery of silica-gold iron-bearing NP with targeted micro-bubbles or stem cells using magnetic navigation system (n=60) versus (3) stent implantation (n=60). The primary outcome was TAV at 12 months. Results: The mean TAV reduction at 12 months in nano group was 60.3 mm3 (SD 39.5; min 41.9 mm3, max 94.2 mm3; p<0.05) up to mean 37.8% (95% CI: 31.1%, 51.7%; p<0.05) plaque burden. The analysis of the event free survival of the ongoing clinical follow-up shows the significantly lower risk of cardiovascular death in nano group when compared with others (91.7% vs 81.7% and 80% respectively; p<0.05) with no cases of the target lesion-related complications. Conslusions: PPTT using silica-gold NP associated with significant regression of coronary atherosclerosis. © 2013 Kharlamov AN, et al.
Author keywords:
Atheroregression; Nanomedicine; Plasmonic photothermal therapy; Silica-gold nanoparticles; Stenting
Index keywords:
acetylsalicylic acid; angiotensin receptor antagonist; atorvastatin; beta adrenergic receptor blocking agent; calcium channel blocking agent; clopidogrel; diuretic agent; glyceryl trinitrate; gold nan
DOI:
10.4172/2157-7439.1000160
Смотреть в Scopus:
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84877868900&doi=10.4172%2f2157-7439.1000160&partnerID=40&md5=f62a8c5b9b71b28b9d898a6296f08fa5
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Link https://www.scopus.com/inward/record.uri?eid=2-s2.0-84877868900&doi=10.4172%2f2157-7439.1000160&partnerID=40&md5=f62a8c5b9b71b28b9d898a6296f08fa5
Affiliations Department of Science, Ural Institute of Cardiology, Yekaterinburg, Russian Federation; Rotterdam University Medical Center (Erasmus MC), Rotterdam, Netherlands; Ural Center of Modern Nanotechnologies, Institute of Natural Sciences, Ural Federal University, Yekaterinburg, Russian Federation; Department of Pathology, Ural State Medical University, Yekaterinburg, Russian Federation
Author Keywords Atheroregression; Nanomedicine; Plasmonic photothermal therapy; Silica-gold nanoparticles; Stenting
Chemicals/CAS acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; atorvastatin, 134523-00-5, 134523-03-8; clopidogrel, 113665-84-2, 120202-66-6, 90055-48-4, 94188-84-8; glyceryl trinitrate, 55-63-0, 80738-44-9; heparin, 37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5; hirulog, 128270-60-0; rosuvastatin, 147098-18-8, 147098-20-2
Tradenames XIENCE V, Abbott Vascular, United States
Manufacturers Abbott Vascular, United States
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Correspondence Address Kharlamov, A. N.; Rotterdam University Medical Center (Erasmus MC)/ Cardialysis B.V, Westblaak 92, entrance B, RM 2.05, Netherlands; email: drkharlamov@icloud.com
Publisher OMICS Publishing Group
Language of Original Document English
Abbreviated Source Title J. Nanomedicine Nanotechnology
Source Scopus