Assessment of comparative toxicity of nano- and microparticles magnetite / Katsnelson B.A., Privalova L.I., Degtyareva T.D., Kuzmin S.V., Sutunkova M.P., Minigalieva I.A., Kireyeva E.P., Khodos M.Y., Shur V.Y., Nikolaeva E.V., Valamina I.E., Tulakina L.G., Pichugova S.V., Beykin J.B. // Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011. - 2011. - V. 3, l. . - P. 537-540.

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Type:
Conference Paper
Abstract:
The key mechanism of pulmonary region's clearance from deposited particles is recruitment of phagocytizing cells on its free surface. Phagocytosis hinders penetration of these particles into pulmonary interstices and thus promotes mucociliary clearance[1]. The alveolar macrophage (AM) is the main cell effector of phagocytosis-mediated pulmonary clearance, the neutrophile leukocyte (NL) being the most important auxiliary one. NLs recruitment is controlled by the number of destroyed AMs. That's why the intensity of NLs recruitment toward deposited particles depends quantitatively on their cytotoxicity for macrophages[1-5]. Thus NL/AM ratio may be used as a criterion of comparative cytotoxicity of particles. Another nano-toxicological problem of theoretical and practical importance is the size-dependence of the comparative resorptive toxicity of particles of substances that are deemed innocuous in bulk.
Author keywords:
Magnetite; Nanoparticles; Subchronic toxicity
Index keywords:
Alveolar macrophages; Comparative toxicity; Free surfaces; Micro-particles; Mucociliary clearance; Practical importance; Size-dependence; Subchronic; Antigen-antibody reactions; Employment; Fluidics;
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Link https://www.scopus.com/inward/record.uri?eid=2-s2.0-81455132680&partnerID=40&md5=34522d66b7e7106623f28c053c031dc8
Affiliations Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Russian Federation; Scientific Production and Innovation Association Ltd., Ekaterinburg, Russian Federation; Ural State University, Ekaterinburg, Russian Federation; Ural State Medical Academy, Ekaterinburg, Russian Federation; Municipal Agency Clinical and Diagnostic Center, Ekaterinburg, Russian Federation
Author Keywords Magnetite; Nanoparticles; Subchronic toxicity
References Katsnelson, B.A., Alekseyeva, O.G., Privalova, L.I., Polzik, E.V., (1995) Pneumoconioses: The Pathogenesis and the Biological Prophylaxis, p. 325. , Ekaterinburg: the Urals Branch of RAS; Katsnelson, B.A., Privalova, L.I., Recruitment of phagocytizing cells into the respiratory tract as a response to the cytotoxic action of deposited particles (1984) Environmental Health Perspectives, VOL. 55, pp. 313-325; Katsnelson, B.A., Konysheva, L.K., Privalova, L.I., Morosova, K., Development of a multicompartmental model of the kinetics of quartz dust in the pulmonary region of the lung during chronic inhalation exposure of rats (1992) Brit J Ind Med., 49, pp. 172-181; Katsnelson, B.A., Konyscheva, L.K., Sharapova, N.Y., Privalova, L.I., Prediction of the comparative intensity of pneumoconiotic changes caused by chronic inhalation exposure to dusts of different cytotoxicity by means of a mathematical model (1994) Occupational and Environmental Medicine, 51 (3), pp. 173-180; Katsnelson, B.A., Konysheva, L.K., Privalova, L.I., Sharapova, N.Y., Quartz dust retention in rat lungs under chronic exposure simulated by a multicompartmental model: Further evidence of the key role of the cytotoxicity of quartz particles (1997) Inhalation Toxicology, 9 (8), pp. 703-715; Katsnelson, B.A., Privalova, L.I., Kuzmin, S.V., Some peculiarities of pulmonary clearance mechanisms in rats after intratracheal instillation of magnetite (Fe3O4) suspensions with different particles size in nanometer and micrometer ranges - Are we defenseless against nanoparticles? (2010) Internat J Environm and Occupat Health, 16, pp. 503-519
Correspondence Address Katsnelson, B.A.; Medical Research Center for Prophylaxis and Health Protection in Industrial WorkersRussian Federation
Sponsors Clean Technology and Sustainable Industries Organization (CTSI);European Patent Office;Greenberg Traurig;Innovation and Materials Science Institute;Jackson Walker L.L.P.
Conference name Nanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Conference date 13 June 2011 through 16 June 2011
Conference location Boston, MA
Conference code 87283
ISBN 9781439871386
Language of Original Document English
Abbreviated Source Title Tech. Proc. NSTI Nanotechnology Conf. Expo, NSTI-Nanotech
Source Scopus