Mössbauer spectroscopy of the iron cores in human liver ferritin, ferritin in normal human spleen and ferritin in spleen from patient with primary myelofibrosis: Preliminary results of comparative analysis / Oshtrakh M.I., Alenkina I.V., Vinogradov A.V., Konstantinova T.S., Kuzmann E., Semionkin V.A. // BioMetals. - 2013. - V. 26, l. 2. - P. 229-239.

ISSN:
09660844
Type:
Article
Abstract:
Comparative study of human liver ferritin and spleen tissues from healthy human and patient with primary myelofibrosis was carried out using Mössbauer spectroscopy with a high velocity resolution at 295 and 90 K and with a low velocity resolution at 20 K. The results obtained demonstrated that the iron content in patient's spleen in the form of iron storage proteins was about ten times larger than that in normal tissue. However, in the case of patient with primary myelofibrosis the magnetic anisotropy energy barrier differed from that in normal case and, probably, the iron core size was supposed to be slightly larger than that in both normal spleen tissue and normal human liver ferritin in contrast to well-known data for iron overload in patients with thalassemia accompanied by the iron-core size increase. Therefore, the iron overload in the case of patient with primary myelofibrosis may be related to increase in the ferritin content mainly. It was also found that Mössbauer hyperfine parameters for normal and patient's spleen and normal human liver ferritin demonstrated some small differences related, probably, to some small structural variations in the ferritin iron cores of patient's spleen. © 2013 Springer Science+Business Media New York.
Author keywords:
Iron storage proteins; Mössbauer spectroscopy; Primary myelofibrosis; Spleen tissues
Index keywords:
ferritin; iron; anisotropy; article; beta thalassemia; comparative study; controlled study; human; human cell; human tissue; iron overload; iron storage; liver level; Mossbauer spectroscopy; myeloid m
DOI:
10.1007/s10534-012-9602-2
Смотреть в Scopus:
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84877876769&doi=10.1007%2fs10534-012-9602-2&partnerID=40&md5=18ae8d3f4c9e1051b637fe8cc84802ab
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Link https://www.scopus.com/inward/record.uri?eid=2-s2.0-84877876769&doi=10.1007%2fs10534-012-9602-2&partnerID=40&md5=18ae8d3f4c9e1051b637fe8cc84802ab
Affiliations Department of Physical Techniques and Devices for Quality Control, Institute of Physics and Technology, Ural Federal University, Ekaterinburg 620002, Russian Federation; Department of Experimental Physics, Institute of Physics and Technology, Ural Federal University, Ekaterinburg 620002, Russian Federation; Ural State Medical Academy, Repin Str., 3, Ekaterinburg 620028, Russian Federation; Institute of Chemistry, Eötvös Loránd University, Budapest, Hungary
Author Keywords Iron storage proteins; Mössbauer spectroscopy; Primary myelofibrosis; Spleen tissues
Chemicals/CAS ferritin, 9007-73-2; iron, 14093-02-8, 53858-86-9, 7439-89-6; Ferritins, 9007-73-2; Iron, 7439-89-6
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Correspondence Address Oshtrakh, M.I.; Department of Experimental Physics, Institute of Physics and Technology, Ural Federal University, Ekaterinburg 620002, Russian Federation; email: oshtrakh@mail.utnet.ru
CODEN BOMEE
PubMed ID 23460118
Language of Original Document English
Abbreviated Source Title BioMetals
Source Scopus