Heme iron state in various oxyhemoglobins probed using Mössbauer spectroscopy with a high velocity resolution / Oshtrakh M.I., Berkovsky A.L., Kumar A., Kundu S., Vinogradov A.V., Konstantinova T.S., Semionkin V.A. // BioMetals. - 2011. - V. 24, l. 3. - P. 501-512.

ISSN:
09660844
Type:
Conference Paper
Abstract:
A comparative study of oxyhemoglobins from pig, rabbit, normal human and patients with blood system malignant diseases was performed using Mössbauer spectroscopy with a high velocity resolution at 90 K. Mössbauer spectra were fitted with the help of two models: using one quadrupole doublet (model of equivalent iron electronic structure in α- and β-subunits of hemoglobins) and superposition of two quadrupole doublets (model of non-equivalent iron electronic structure in α- and β-subunits of hemoglobins). The results obtained using both models demonstrated small variations of hyperfine parameters that were related to the heme iron state variation in different hemoglobins. These results were compared with structural and functional differences of the hemoglobins investigated. © 2010 Springer Science+Business Media, LLC.
Author keywords:
Heme iron; Mössbauer spectroscopy with a high velocity resolution; Oxyhemoglobins; Quadrupole splitting
Index keywords:
heme iron; hemoglobin alpha chain; hemoglobin beta chain; iron; oxyhemoglobin; unclassified drug; animal cell; comparative study; conference paper; controlled study; human; human cell; malignant neopl
DOI:
10.1007/s10534-011-9428-3
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Affiliations Faculty of Physical Techniques and Devices for Quality Control, Ural Federal University, Ekaterinburg 620002, Russian Federation; Hematological Research Center, Russian Academy of Sciences, Moscow 125167, Russian Federation; Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, New Delhi 110021, India; Ural State Medical Academy, Repin str., 3, Ekaterinburg 620028, Russian Federation; Faculty of Experimental Physics, Ural Federal University, Ekaterinburg 620002, Russian Federation
Author Keywords Heme iron; Mössbauer spectroscopy with a high velocity resolution; Oxyhemoglobins; Quadrupole splitting
Chemicals/CAS iron, 14093-02-8, 53858-86-9, 7439-89-6; oxyhemoglobin, 9061-63-6; Heme, 14875-96-8; Hemoglobins; Iron, 7439-89-6; Oxyhemoglobins; Protein Subunits
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Correspondence Address Oshtrakh, M.I.; Faculty of Physical Techniques and Devices for Quality Control, Ural Federal University, Ekaterinburg 620002, Russian Federation; email: oshtrakh@mail.utnet.ru
CODEN BOMEE
PubMed ID 21350949
Language of Original Document English
Abbreviated Source Title BioMetals
Source Scopus