Determination of the iron state in ferrous iron containing vitamins and dietary supplements: Application of Mössbauer spectroscopy / Oshtrakh M.I., Milder O.B., Semionkin V.A. // Journal of Pharmaceutical and Biomedical Analysis. - 2006. - V. 40, l. 5. - P. 1281-1287.

ISSN:

07317085

Type:

Article

Abstract:

Determination of the iron state in commercially manufactured iron containing vitamins and dietary supplements is important for evaluation of pharmaceuticals quality. Mössbauer (nuclear gamma-resonance) spectroscopy was used for analyzing the iron state in commercial pharmaceutical products containing ferrous fumarate (FeC4H2O4), ferrous sulfate (FeSO4), ferrous bisglycinate chelate (Ferrochel ®) and ferrous iron (hydrolyzed protein chelate). Mössbauer parameters and the iron states were determined for iron compounds in the studied pharmaceuticals. Various ferric and ferrous impurities were found in all of the commercial products. The quantities of ferric impurities exceeded the FDA limitation of 2% in products containing ferrous fumarate. The quantities of ferric impurities exceeded 58% and 30% in products containing ferrous bisglycinate chelate and ferrous iron (hydrolyzed protein chelate), respectively. The presence of ferrous and ferric impurities was not related to the ageing of the vitamins and dietary supplements. Two pharmaceutical products contained major iron compounds, the Mössbauer parameters of which did not correspond to the ferrous fumarate or ferrous bisglycinate chelate claimed by the manufacturer. © 2005 Elsevier B.V. All rights reserved.

Author keywords:

Ferrous bisglycinate chelate (Ferrochel®); Ferrous fumarate; Ferrous iron (hydrolyzed protein chelate); Ferrous sulfate; Iron state; Mössbauer spectroscopy; Vitamins and dietary supplements

Index keywords:

centrum; essential balance; ferrous bisglycinate chelate; ferrous fumarate; ferrous ion; ferrous sulfate; iron derivative; maximum pak; multivitamin; my favorite; take one; unclassified drug; womens u

DOI:

10.1016/j.jpba.2005.09.020

Смотреть в Scopus:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-32644476696&doi=10.1016%2fj.jpba.2005.09.020&partnerID=40&md5=2110aa221933954bff6f1ecdf0f8ae14

Соавторы в МНС:

Другие поля

Поле	Значение
Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-32644476696&doi=10.1016%2fj.jpba.2005.09.020&partnerID=40&md5=2110aa221933954bff6f1ecdf0f8ae14
Affiliations	Division of Applied Biophysics, Faculty of Physical Techniques and Devices for Quality Control, Ural State Technical University - UPI, Ekaterinburg 620002, Russian Federation; Faculty of Experimental Physics, Ural State Technical University - UPI, Ekaterinburg 620002, Russian Federation
Author Keywords	Ferrous bisglycinate chelate (Ferrochel®); Ferrous fumarate; Ferrous iron (hydrolyzed protein chelate); Ferrous sulfate; Iron state; Mössbauer spectroscopy; Vitamins and dietary supplements
Chemicals/CAS	ferrous fumarate, 141-01-5, 7705-12-6; ferrous ion, 15438-31-0; ferrous sulfate, 10028-21-4, 10124-49-9, 13463-43-9, 7720-78-7, 7782-63-0; ferrous bisglycinate; Ferrous Compounds; ferrous fumarate, 141-01-5; ferrous sulfate, 7720-78-7; Glycine, 56-40-6; Iron, 7439-89-6; Vitamins
Tradenames	centrum, Whitehall Robins, United States; essential balance, Nature Made Nutritional Products, United States; feosol, SmithKline Beecham, United States; ferrochel, albion laboratories, United States; maximum pak, Leiner, United States; my favorite, Natrol, United States; take one, Natrol, United States; womens ultra mega, General Nutrition, United States; your life, Leiner, United States
Manufacturers	albion laboratories, United States; Amway, United States; General Nutrition, United States; Leiner, United States; Natrol, United States; Nature Made Nutritional Products, United States; SmithKline Beecham, United States; vita fresh vitamin, United States; Walgreen, United States; western family foods, United States; Whitehall Robins, United States; windmill, United States
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Correspondence Address	Oshtrakh, M.I.; Division of Applied Biophysics, Faculty of Physical Techniques and Devices for Quality Control, Ural State Technical University - UPI, Ekaterinburg 620002, Russian Federation; email: oshtrakh@mail.utnet.ru
CODEN	JPBAD
PubMed ID	16280229
Language of Original Document	English
Abbreviated Source Title	J. Pharm. Biomed. Anal.
Source	Scopus