Diastereoselective synthesis of spiro derivatives of 3-substituted 2,3,4,4a,5,6-hexahydro-1H-benzo[c]quinolizines / Glukhareva T.V., Deeva E.V., Platonova A.Yu., Geide I.V., Kodess M.I., Morzherin Yu.Yu. // Russian Journal of Organic Chemistry. - 2009. - V. 45, l. 5. - P. 743-754.

ISSN:
10704280
Type:
Article
Abstract:
The cyclization via the mechanism of "tert-amino effect" of 2-(4-R-piperidino)benzaldehydes with cyclic active methylene components (Meldrum's acid, 1,3-cyclohexanedione, and N,N-disubstituted barbituric acids) proceeded stereoselectively giving spiro-joined 2,3,4,4a,5,6-hexahydro-1H- benzo[c]quinolizines with axially oriented hydrogen atoms in the positions 3 and 4a of the benzo[c]quinolizine ring. © 2009 Pleiades Publishing, Ltd.
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DOI:
10.1134/S1070428009050170
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Affiliations Ural State Technical University, Yekaterinburg 620002, Russian Federation; Postovskii Institute of Organic Synthesis, Ural Division, Russian Academy of Sciences, Russian Federation
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Correspondence Address Glukhareva, T. V.; Ural State Technical University, Yekaterinburg 620002, Russian Federation
Language of Original Document English
Abbreviated Source Title Russ. J. Org. Chem.
Source Scopus