Synthesis and bioactivity of N-tert-butyl-N′-acyl-5-methyl-1,2,3- thiadiazole-4-carbohydrazides / Mao W.T., Zhao H., Fan Z.J., Ji X.T., Hua X.W., Kalinina T., Yury Y.M., Vasiliy A.B. // Chinese Chemical Letters. - 2012. - V. 23, l. 11. - P. 1233-1236.

ISSN:

10018417

Type:

Article

Abstract:

A series of novel N-tert-butyl-N′-acyl-5-methyl-1,2,3-thiadiazole-4- carbohydrazides were designed and synthesized. Their structures were characterized by melting points, 1H NMR, IR, ESI-MS, and elemental analysis. The bioassay tests indicated that compound 7o exhibited excellent direct anti-TMV activity and induction activity in vivo at 50 μg/mL, which was better than that of Ninamycin and tiadinial. Our studies indicated that 1,2,3-thiadiazole was an active substructure for novel pesticide development. © 2012 Zhi Jin Fan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

Author keywords:

1,2,3-Thiadiazole; Antivirus activity; Diacylhydrazine; Synthesis; Systemic acquired resistance

Index keywords:

нет данных

DOI:

10.1016/j.cclet.2012.09.024

Смотреть в Scopus:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84868450495&doi=10.1016%2fj.cclet.2012.09.024&partnerID=40&md5=38b76b6e01cefa5577578f2b1d82d28b

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Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84868450495&doi=10.1016%2fj.cclet.2012.09.024&partnerID=40&md5=38b76b6e01cefa5577578f2b1d82d28b
Affiliations	Department of Chemistry, Tianjin University, Tianjin 300072, China; State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China; Ural Federal University Named after the First President of Russia B.N. Yeltsin, Yeltsin UrFU 620002, Ekaterinburg, Russian Federation
Author Keywords	1,2,3-Thiadiazole; Antivirus activity; Diacylhydrazine; Synthesis; Systemic acquired resistance
References	Fan, Z.J., Liu, X.F., Liu, F.L., (2005) Acta Phytophyl. Sin., 32, p. 87; Gozzo, F., (2003) J. Agric. Food Chem., 51, p. 4487; Yasuda, M., Kusajima, M., Nakajima, M., (2010) J. Pestic. Sci., 31, p. 329; Fan, Z.J., Shi, Z.G., Zhang, H.K., (2009) J. Agric. Food Chem., 57, p. 4279; Du, Q.S., Zhu, W.P., Zhao, Z.J., (2012) J. Agric. Food Chem., 60, p. 346; Zhan, P., Liu, X.Y., Li, Z.Y., (2009) Bioorg. Med. Chem., 17, p. 5920; Liu, X.H., Pan, L., Weng, J.Q., (2012) Mol. Divers, 16, p. 251; Chen, Y.F., Zhang, C.R., Huang, X., (2006) Plant Phys. Commun., 42, p. 127; Liu, X.H., Wang, J.Q., Tan, C.X., (2011) Asian J. Chem., 23, p. 4064; Tang, W.M., He, X.Q., Song, V.A., (2004) Chin. J. Org. Chem., 24, p. 1288; Wang, H., Yang, Z.K., Fan, Z.J., (2011) J. Agric. Food Chem., 59, p. 628; Nombela, G., Pascual, S., Aviles, M., (2005) J. Econ. Entomol., 98, p. 2266; Sun, R.F., Zhang, Y.L., Chen, L., (2009) J. Agric. Food Chem., 57, p. 3661; Shang, J., Sun, R.F., Li, Y.Q., (2010) J. Agric. Food Chem., 58, p. 1834; Ruiu, L., Satta, A., Floris, I., (2008) Biol. Control, 47, p. 66; Burdzinski, G., Sliwa, M., Zhang, Y.L., (2011) J. Phys. Chem. A, 115, p. 14300; Zhang, D.Q., Xu, G.F., Fan, Z.J., (2012) Chin. Chem. Lett., 23, p. 669; Yuan, D.K., Zhang, D.Q., Li, R.X., (2011) Chin. Chem. Lett., 22, p. 18; Shafiee, A., (1976) J. Heterocyclic Chem., 13, p. 301
Correspondence Address	Fan, Z.J.; State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China; email: fanzj@nankai.edu.cn
CODEN	CCLEE
Language of Original Document	English
Abbreviated Source Title	Chin. Chem. Lett.
Source	Scopus