Models of active transport of ions in biomembranes of various types of cells / Melkikh A.V., Seleznev V.D. // Journal of Theoretical Biology. - 2005. - V. 234, l. 3. - P. 403-412.

ISSN:

00225193

Type:

Article

Abstract:

Nonequilibrium statistical models of the active transport of ions in biomembranes have been constructed. Differences of chemical potentials of the ATP-ADP reaction and the electrochemical potential of ions were taken as the thermodynamic forces responsible for the flow of ions through the membrane. The active transport of ions was viewed as a cross phenomenon arising from the chemical reaction of the ATP hydrolysis. These models provide independent calculations of the resting potential at the biomembrane and concentrations of ions in a cell on the assumption the free energy of the ATP-ADP reaction is fully (without the dissipation loss) converted to the free energy of transported ions. They take into account the presence of nonpenetrating ions in a cell. It was shown that different concentrations of nonpenetrating ions have a considerable effect on the resting potential. The proposed models were compared with experimental data obtained for different types of cells including neurons, muscular cells, bacteria, plants, and mitochondria. Calculated values of the membrane potential and ion concentrations were in good qualitative agreement with experimental data. © 2005 Elsevier Ltd. All rights reserved.

Author keywords:

Active transport of ions; Nonpenetrating ions; Resting potential

Index keywords:

adenosine diphosphate; adenosine triphosphate; membrane; signal; active transport; article; bacterial cell; calculation; cell type; chemical reaction; electrochemical analysis; energy; hydrolysis; ion

DOI:

10.1016/j.jtbi.2004.12.002

Смотреть в Scopus:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-15244361209&doi=10.1016%2fj.jtbi.2004.12.002&partnerID=40&md5=19fedee6c91655b66a65f8c9c1234d7f

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Другие поля

Поле	Значение
Link	https://www.scopus.com/inward/record.uri?eid=2-s2.0-15244361209&doi=10.1016%2fj.jtbi.2004.12.002&partnerID=40&md5=19fedee6c91655b66a65f8c9c1234d7f
Affiliations	Molecular Physics Department, Ural State Technical University, 19 Mira street, 620002 Ekaterinburg, Russian Federation
Author Keywords	Active transport of ions; Nonpenetrating ions; Resting potential
Chemicals/CAS	adenosine diphosphate, 20398-34-9, 58-64-0; adenosine triphosphate, 15237-44-2, 56-65-5, 987-65-5
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Correspondence Address	Melkikh, A.V.; Molecular Physics Department, Ural State Technical University, 19 Mira street, 620002 Ekaterinburg, Russian Federation; email: mav@dpt.ustu.ru
Publisher	Academic Press
CODEN	JTBIA
PubMed ID	15784274
Language of Original Document	English
Abbreviated Source Title	J. Theor. Biol.
Source	Scopus