Synthesis and biological activities of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives / Li F.-Y., Guo X.-F., Fan Z.-J., Zhang Y.-Q., Zong G.-N., Qian X.-L., Ma L.-Y., Chen L., Zhu Y.-J., Tatiana K., Morzherin Y.Y., Belskaya N.P. // Chinese Chemical Letters. - 2015. - V. 26, l. 10. - P. 1315-1318.

ISSN:
10018417
Type:
Article
Abstract:
A series of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives were designed and synthesized. Their structures were confirmed by melting points, IR, 1H NMR, 13C NMR, and HRMS or elemental analysis. Biological activities of all title compounds including fungicidal activity and antivirus activity were evaluated systematically. Preliminary bioassays indicated that these compounds exhibited good fungicidal activity at 50 μg/mL, compounds 4b and 4i exhibited over 50% activity against six fungi tested. Most compounds showed good activity against TMV with different models in vivo at 100 μg/mL. Compounds 4c and 4e stood out with high effects against TMV in vivo in all models tested, including protective, inactivative, curative, and inductive activities. These data demonstrate a new strategy for fungi and virus control. © 2015 Elsevier Ltd. All rights reserved.
Author keywords:
1,3-Thiazole derivatives; Anti-TMV activity; Fungicidal activity
Index keywords:
нет данных
DOI:
10.1016/j.cclet.2015.05.040
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937126463&doi=10.1016%2fj.cclet.2015.05.040&partnerID=40&md5=7067b8970810e77566f29f4b13b6d2b0
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Link https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937126463&doi=10.1016%2fj.cclet.2015.05.040&partnerID=40&md5=7067b8970810e77566f29f4b13b6d2b0
Affiliations State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin, China; Ural Federal University Named after the First President of Russia B. N. Yeltsin, Ekaterinburg, Russian Federation
Author Keywords 1,3-Thiazole derivatives; Anti-TMV activity; Fungicidal activity
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Correspondence Address Fan, Z.-J.; State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai UniversityChina; email: fanzj@nankai.edu.cn
Publisher Elsevier B.V.
CODEN CCLEE
Language of Original Document English
Abbreviated Source Title Chin. Chem. Lett.
Source Scopus