New Opportunities for the Synthesis of Quinoxaline-Substituted Heterocyclic and Aryl Moieties / Azev Yu. A.,Kodess M. I.,Ezhikova M. A.,Gibor A. M.,Baranov V. I.,Ermakova O. S.,Bakulev V. A. // PHARMACEUTICAL CHEMISTRY JOURNAL. - 2013. - V. 47, l. 9. - P. 498-502.

ISSN/EISSN:

0091-150X / 1573-9031

Type:

Article

Abstract:

6.7-Difluoroquinoxaline (I) reacted with dimedone, indandione, and 3-methyl-1-phenylpyrazol-5-one in DMSO solution in the presence of acid to form mono-substituted products IIa - c. Heating I with resorcinol in EtOH in the presence of acid gave resorcinol derivative IId. 6.7-Difluoroquinoxaline in the presence of base reacted with 3-methyl-1-phenylmethylpyrazol-5-one to form dipyrazolylmethane III and tetrapyrazolylethane derivative IV. Heating products IIa - c with N-methylpiperazine produced 7-methylpiperazine derivatives Va - c of 2-substituted quinoxalines.

Author keywords:

6.7-difluoroquinoxaline; reactions with nucleophiles

DOI:

10.1007/s11094-013-0989-z

Web of Science ID:

ISI:000328839300011

Соавторы в МНС:

Другие поля

Поле	Значение
Month	DEC
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-9031
Research-Areas	Pharmacology \& Pharmacy
Web-of-Science-Categories	Chemistry, Medicinal; Pharmacology \& Pharmacy
Author-Email	azural@yandex.ru
Funding-Acknowledgement	RFBR {[}11-03-00579-a]
Funding-Text	We thank the RFBR (Grant No. 11-03-00579-a) for financial support.
Number-of-Cited-References	10
Usage-Count-Last-180-days	2
Usage-Count-Since-2013	12
Journal-ISO	Pharm. Chem. J.
Doc-Delivery-Number	277SJ