Synthesis of 3,5-Dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl Containing 1,2,3-Thiadiazole Derivatives via Ugi Reaction and Their Biological Activities / Wang Shouxin ,Wang Huan ,Fan Zhijin ,Fu Yifeng ,Mi Na ,Zhang Jufang ,Zhang Zhengcai ,Belskaya Nataliya P.,Bakulev Vasiliy A. // CHINESE JOURNAL OF CHEMISTRY. - 2011. - V. 29, l. 2. - P. 288-296.

ISSN/EISSN:

1001-604X / нет данных

Type:

Article

Abstract:

A series of novel 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl containing 4-methyl-1,2,3-thiadiazole derivatives were designed and synthesized via Ugi reaction. Their structures were confirmed by IR, (1)H NMR, (13)C NMR and high-resolution mass spectroscopy. The preliminary bioassay results indicated that some title compounds had good fungicide activity at 50 mu g/mL; most of the compounds presented a certain degree of direct inhibition activity, good inactivation and curative activity against tobacco mosaic virus at 500 mu g/mL and 100 mu g/mL; some compounds showed good larvicidal activity against Plutella xylostella L. at 200 mu g/mL and excellent larvicidal activities against Culex pipiens pallens at 2 mu g/mL.

Author keywords:

1,2,3-thiadiazole; Ugi reaction; synthesis design; biological activity; multicomponent reactions RESISTANCE; ELICITORS; LIBRARY

DOI:

10.1002/cjoc.201190080

Web of Science ID:

ISI:000287819700012

Соавторы в МНС:

Другие поля

Поле	Значение
Month	FEB
Publisher	WILEY-BLACKWELL
Address	COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Language	English
Keywords-Plus	RESISTANCE; ELICITORS; LIBRARY
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	fanzj@nankai.edu.cn
ResearcherID-Numbers	Belskaya, Nataliya/S-3953-2017
ORCID-Numbers	Belskaya, Nataliya/0000-0002-2509-7916
Funding-Acknowledgement	National Natural Science Foundation of China {[}20872071, 20911120069]; Tianjin Natural Science Foundation {[}10JCZDJC17500]; National Key Project for Basic Research {[}2010CB126105]; National Key Technology Research and Development Program {[}2011BAE06B02, 2011BAE06B05]; Foundation of Achievements Transformation and Spreading of Tianjin Agricultural Science and Technology {[}201002250]; Russian Foundation for Basic Research {[}RFBR 08-03-00376 a, RFBR/NNSF 08-03-92208 a]
Funding-Text	Project supported by the National Natural Science Foundation of China (Nos. 20872071, 20911120069), the Tianjin Natural Science Foundation (No. 10JCZDJC17500), the National Key Project for Basic Research (No. 2010CB126105), the National Key Technology Research and Development Program (Nos. 2011BAE06B02, 2011BAE06B05) and the Foundation of Achievements Transformation and Spreading of Tianjin Agricultural Science and Technology (No. 201002250), the Russian Foundation for Basic Research (Nos. RFBR 08-03-00376 a and RFBR/NNSF 08-03-92208 a).
Number-of-Cited-References	27
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	8
Journal-ISO	Chin. J. Chem.
Doc-Delivery-Number	727RU