Synthesis, Crystal Structure and Biological Activity of N-tert-butyl-N-(4-methyl-1,2,3-thiadiazole)-5-yl-N `-(4-methyl-1,2,3-thiadiazole)-5-formyl-N `-3,5-dichloropyridin-2-yl-diacylhydrazine / Wang Huan ,Fu Yi-Feng ,Fan Zhi-Jin ,Song Hai-Bin ,Wu Qing-Jun ,Zhang You-Jun ,Belskaya N. P.,Bakulev V. A. // CHINESE JOURNAL OF STRUCTURAL CHEMISTRY. - 2011. - V. 30, l. 3. - P. 412-416.

ISSN/EISSN:

0254-5861 / нет данных

Type:

Article

Abstract:

The title compound N-tert-butyl-N-(4-methyl-1,2,3-thiadiazole)-5-yl-N'-(4-me-thyl-1,2,3-thi adiazole)-5-formyl-N'-3,5-dichloropyrid-2-yl-diacylhydrazines (C(18)H(17)C(12)N(7)O(3)S(2), M(r) = 514.41) has been synthesized by the reaction of N-tert-butyl-N'-3,6-dichloropyridine-2-formyl hydrazine with 4-methyl-1,2,3- thiadiazole-5-carbonyl chloride and triethylamine, and its structure was characterized by (1)H NMR, FIR MS, and single-crystal X-ray diffraction. The crystal of the title compound belongs to monoclinic, space group C2/c with a = 27.726(8), b = 11.045(3), c = 14.507(4) angstrom, beta = 96.758(4)degrees, Z = 8, V = 4412(2) angstrom(3), D(c) = 1.549 g/cm(3), mu = 0.521 mm(-1), F(000) = 2112, R = 0.0405 and wR = 0.1153. X-ray analysis indicates that all rings are non-planar in this molecule. The bioassay results indicate that both the title compound and the positive control RH-5992 have weak fungicide activities, while the title compound has good insecticidal activity against Plutella xylostella L. and no insecticidal activity against Culex pipiens pallens.

Author keywords:

crystal structure; 1,2,3-thiadiazole; synthesis; biological activity SYSTEMIC ACQUIRED-RESISTANCE; HALOGEN BOND; AGONIST

DOI:

нет данных

Web of Science ID:

ISI:000289044000018

Соавторы в МНС:

Другие поля

Поле	Значение
Publisher	CHINESE JOURNAL STRUCTURAL CHEMISTRY
Address	FUIJAN INST RES STRUCT MATTER, CHINESE ACAD SCIENCES, FUZHOU, FUJIAN 350002, PEOPLES R CHINA
Language	English
Keywords-Plus	SYSTEMIC ACQUIRED-RESISTANCE; HALOGEN BOND; AGONIST
Research-Areas	Chemistry; Crystallography
Web-of-Science-Categories	Chemistry, Inorganic \& Nuclear; Crystallography
Author-Email	fanzj@nankai.edu.cn
ResearcherID-Numbers	Belskaya, Nataliya/S-3953-2017
ORCID-Numbers	Belskaya, Nataliya/0000-0002-2509-7916
Funding-Acknowledgement	NNSFC {[}20872071, 20672062, 20911120069]; NSF of Tianjin {[}10JCZDJC17500]; National Key Project for Basic Research {[}2010CB126105]; Foundation of Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture (MOA) {[}MOAPCA200903]; Russian Foundation for Basic Research {[}RFBR 08-03-00376a, RFBR/NNSF 08-03-92208a]; Foundation of Achievements Transformation and Spreading of Tianjin Agricultural Science and Technology {[}201002250]
Funding-Text	This study was funded in part by the NNSFC (Nos. 20872071, 20672062 and 20911120069), the NSF of Tianjin (10JCZDJC17500), the National Key Project for Basic Research (2010CB126105) and the Foundation of Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture (MOA) (No. MOAPCA200903); the Russian Foundation for Basic Research (grant numbers RFBR 08-03-00376a and RFBR/NNSF 08-03-92208a); the Foundation of Achievements Transformation and Spreading of Tianjin Agricultural Science and Technology (No. 201002250)
Number-of-Cited-References	18
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	4
Journal-ISO	Chin. J. Struct. Chem.
Doc-Delivery-Number	743UK