Synthesis and oxidative cyclization of 2-arylhydrazono-2-cyanoacetamidines to 5-amino-2-aryl-2H-{[}1,2,3]triazole-4-carbonitrile / Bel'skaya Natalia P.,Demina Marina A.,Sapognikova Svetlana G.,Fan Zhi-Jin,Zhang Hai-Ke,Dehaen Wim,Bakulev Vasiliy A. // ARKIVOC. - 2008. - V. , l. . - P. 9-21.

ISSN/EISSN:
1424-6376 / нет данных
Type:
Article
Abstract:
A general and convenient method for the synthesis of 2-arylhydrazono-2-cyanoacetamidines, containing either a cytisine or tryptamine moiety, or other secondary and primary amines was elaborated. A series of 5-amino-2-aryl-2H-{[}1,2,3]-triazole-4-carbonitriles was successfully prepared by oxidation of these amidines with copper acetate in pyridine. The screening of the biological activity of the synthesized triazoles and amidines have shown that, some of these compounds possess fungicidal activity at concentrations of 50 mu g/mL against some fungi tested.
Author keywords:
Amidines; cytisine; tryptamine; oxydation; 1,2,3-triazole; fungicide activity NITRIC-OXIDE SYNTHASE; IN-VIVO; SELECTIVE INHIBITORS; PHASE SYNTHESIS; AMIDINES; DERIVATIVES; METABOLISM; ANALOGS; POTENT; AGENTS
DOI:
нет данных
Web of Science ID:
ISI:000263106900002
Соавторы в МНС:
Другие поля
Поле Значение
Publisher ARKAT USA INC
Address C/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX 117200, GAINESVILLE, FL 32611 USA
Language English
Keywords-Plus NITRIC-OXIDE SYNTHASE; IN-VIVO; SELECTIVE INHIBITORS; PHASE SYNTHESIS; AMIDINES; DERIVATIVES; METABOLISM; ANALOGS; POTENT; AGENTS
Research-Areas Chemistry
Web-of-Science-Categories Chemistry, Organic
Author-Email belska@mail.ustu.ru
ResearcherID-Numbers Belskaya, Nataliya/S-3953-2017
ORCID-Numbers Belskaya, Nataliya/0000-0002-2509-7916
Funding-Acknowledgement Russian Foundation {[}08-03-00376-a]; National Natural Science Foundation of China {[}20672062]; National Key Project {[}2003CB114402]; Tianjin Natural Science Foundation {[}07JCYBJC01200]; International Collaboration Program of Tianjin on Science and Technology {[}07ZCGHHZ01400]
Funding-Text The authors thank the Russian Foundation for Basic Research for financial support (grant RFFI no. 08-03-00376-a), the National Natural Science Foundation of China (No. 20672062), the National Key Project for Basic Research (No. 2003CB114402), the Tianjin Natural Science Foundation (No. 07JCYBJC01200) and International Collaboration Program of Tianjin on Science and Technology (No. 07ZCGHHZ01400). W. D. thanks the University of Leuven and the F. W. O.
Number-of-Cited-References 37
Usage-Count-Last-180-days 1
Usage-Count-Since-2013 5
Journal-ISO Arkivoc
Doc-Delivery-Number 403UG