8-Alkyl{[}1,2,4]Triazolo{[}5,1-b]Purines / Savateev K. V.,Ulomsky E. N.,Borisov S. S.,Voinkov E. K.,Fedotov V. V.,Rusinov V. L. // CHEMISTRY OF HETEROCYCLIC COMPOUNDS. - 2014. - V. 50, l. 6. - P. 880-887.

ISSN/EISSN:

0009-3122 / 1573-8353

Type:

Article

Abstract:

A novel method has been developed for the synthesis of 8-alkyl{[}1, 2, 4]triazolo{[}5,1-b]purines from 6-nitro{[}1,2,4]triazolo{[}1,5-a]pyrimidin-7-ones via successive phosphoryl chloride-mediated chloro-desoxygenation, aminodehalogenation, and reduction to give 7-alkylamino-6-amino{[}1,2,4]triazolo-{[}1,5-a]pyrimidines. The latter can be cyclized in the presence of formic acid.

Author keywords:

anomalous nucleosides; nitrogen heterocycles; purines; triazolopyrimidines; chlorodesoxygenation; nitro group reduction ANTIVIRAL ACTIVITY; RECEPTOR ANTAGONISTS; DERIVATIVES; ADENOSINE; INHIBITION; ANALOGS; ACID

DOI:

10.1007/s10593-014-1542-z

Web of Science ID:

ISI:000340878300010

Соавторы в МНС:

Другие поля

Поле	Значение
Month	SEP
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-8353
Keywords-Plus	ANTIVIRAL ACTIVITY; RECEPTOR ANTAGONISTS; DERIVATIVES; ADENOSINE; INHIBITION; ANALOGS; ACID
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	ulomsky@yandex.ru
Funding-Acknowledgement	Russian Scientific Fund {[}14-13-01301]
Funding-Text	This work was carried out with the financial support of the Russian Scientific Fund (project 14-13-01301).
Number-of-Cited-References	26
Usage-Count-Last-180-days	6
Usage-Count-Since-2013	27
Journal-ISO	Chem. Heterocycl. Compds.
Doc-Delivery-Number	AN8TV