Addition of C-nucleophiles to 5-phenylpyrimidin-2(1H)-ones and 6-phenyl-1,2,4-triazin-3(2H)-one / Egorov Ilya N.,Tseitler Tatyana A.,Zyryanov Grigory V.,Rusinov Vladimir L.,Chupakhin Oleg N. // ARKIVOC. - 2011. - V. , l. 10. - P. 323-334.

ISSN/EISSN:

1551-7004 / нет данных

Type:

Article

Abstract:

Addition reactions of C-nucleophiles to the C=N bond of 5-phenyl- and 1-methyl-5-phenylpyrimidin-2(1H)-ones 1a,b and 6-phenyl-1,2,4-triazin-3(2H)-one 2 were investigated. 1a, b and 2 furnished addition products with indoles; 1a also added N-methylpyrrole. Only 2 added thiophene and methyl ketones, and reacted with alkyl halides and acetone forming products resulting both from alkylation and from addition of acetone at positions 2 and 5, respectively.

Author keywords:

Pyrimidinones; 1,2,4-triazinones; indoles; nucleophilic addition reactions; aza-Friedel-Crafts reactions FRIEDEL-CRAFTS REACTION; ANTIVIRAL ACTIVITY; 2-PYRIMIDINONE NUCLEOSIDES; AROMATIC-SUBSTITUTION; BIOLOGICAL-ACTIVITIES; DERIVATIVES; PYRIMIDIN-2(1H)-ONES; IDENTIFICATION; PYRIMIDINE; PRODUCTS

DOI:

нет данных

Web of Science ID:

ISI:000297767300026

Соавторы в МНС:

Другие поля

Поле	Значение
Publisher	ARKAT USA INC
Address	C/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX 117200, GAINESVILLE, FL 32611 USA
Language	English
Keywords-Plus	FRIEDEL-CRAFTS REACTION; ANTIVIRAL ACTIVITY; 2-PYRIMIDINONE NUCLEOSIDES; AROMATIC-SUBSTITUTION; BIOLOGICAL-ACTIVITIES; DERIVATIVES; PYRIMIDIN-2(1H)-ONES; IDENTIFICATION; PYRIMIDINE; PRODUCTS
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	i.n.egorov@gmail.com chupakhin@ios.uran.ru
Funding-Acknowledgement	Russian Federation {[}MK-1157.2009.3]; Ural Federal University
Funding-Text	We are pleased to thank Dr. P. Slepukhin for assistance with the X-ray analysis. This work was supported by the program of the Russian Federation President for government support of young scientists, MK-1157.2009.3, and by the program on carrying out of scientific researches by candidates of science and post-graduate students of Ural Federal University.
Number-of-Cited-References	45
Usage-Count-Last-180-days	3
Usage-Count-Since-2013	20
Journal-ISO	Arkivoc
Doc-Delivery-Number	858AF