1,2,4-Triazoloazine derivatives as a new type of herpes simplex virus inhibitors / Deev S. L.,Yasko M. V.,Karpenko I. L.,Korovina A. N.,Khandazhinskaya A. L.,Andronova V. L.,Galegov G. A.,Shestakova T. S.,Ulomskii E. N.,Rusinov V. L.,Chupakhin O. N.,Kukhanova M. K. // BIOORGANIC CHEMISTRY. - 2010. - V. 38, l. 4-6. - P. 265-270.

ISSN/EISSN:

0045-2068 / нет данных

Type:

Article

Abstract:

A new class of inhibitors of herpes simplex virus replication was found. The compounds under study are derived from condensed 1,2,4-triazolo{[}5,1-c]{[}1,2,4]triazines and 1,2,4-triazolo{[}1,5-a]pyrimidines, structural analogues of natural nucleic bases. Antiherpetic activity and cytotoxicity of the compounds were studied. The corresponding triphosphates of several active compounds were prepared and tested as inhibitors of DNA synthesis catalyzed by herpes simplex virus polymerase. The potential mechanism of their action is blocking of DNA dependent DNA polymerase, a key enzyme of viral replication. (C) 2010 Elsevier Inc. All rights reserved.

Author keywords:

Herpes simplex virus; Inhibitors; Nucleoside analogues; Triazoloazine derivatives HETEROSUBSTITUTED NUCLEOSIDE ANALOGS; TRICYCLIC ANALOGS; ANTIVIRAL DRUGS; ACYCLOVIR; GANCICLOVIR; DISCOVERY; AGENTS

DOI:

10.1016/j.bioorg.2010.09.002

Web of Science ID:

ISI:000285403000021

Соавторы в МНС:

Другие поля

Поле	Значение
Month	AUG-DEC
Publisher	ACADEMIC PRESS INC ELSEVIER SCIENCE
Address	525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
Language	English
Keywords-Plus	HETEROSUBSTITUTED NUCLEOSIDE ANALOGS; TRICYCLIC ANALOGS; ANTIVIRAL DRUGS; ACYCLOVIR; GANCICLOVIR; DISCOVERY; AGENTS
Research-Areas	Biochemistry \& Molecular Biology; Chemistry
Web-of-Science-Categories	Biochemistry \& Molecular Biology; Chemistry, Organic
Author-Email	kukhan86@hotmail.com
ResearcherID-Numbers	Korovina, Anna/R-4908-2016 Karpenko, Inna/F-5879-2015
ORCID-Numbers	Karpenko, Inna/0000-0001-9849-0447 Galegov, Georgy/0000-0001-6162-1650 Deyev, Sergey/0000-0002-3952-0631
Funding-Acknowledgement	Russian Federation on Basic Research {[}08-04-00552, 09-04-12204]; Presidium of Russian Academy of Sciences; {[}02.740.11.0260]; {[}02.522.12.2011]
Funding-Text	This work was supported by Russian Federation on Basic Research Grants 08-04-00552 and 09-04-12204, Presidium of Russian Academy of Sciences on ``Molecular and Cellular Biology{''} and State contracts 02.740.11.0260 and 02.522.12.2011.
Number-of-Cited-References	28
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	9
Journal-ISO	Bioorganic Chem.
Doc-Delivery-Number	695WJ