NON-NATURAL NUCLEOSIDES BASED ON 1,2,4-TRIAZOLO{[}1,5-a]PYRIMIDIN-7-ONES / Chupakhin Oleg N.,Shestakova Tatiana S.,Deev Sergey L.,Eltsov Oleg S.,Rusinov Vladimir L. // HETEROCYCLES. - 2010. - V. 80, l. 2. - P. 1149-1163.

ISSN/EISSN:

0385-5414 / нет данных

Type:

Article

Abstract:

Two methods for synthesis of new nucleosides bearing 6-phenyl-1,2,4-triazolo{[}1,5-a]pyrimidin-7-ones as a base have been developed. The first one includes Vorbruggen glycosylation reaction. The second method, which is effective for synthesis of acyclic nucleosides, is based on the condensation between sodium salts of 6-phenyl-1,2,4-triazolo {[}1,5-a]pyrimidin-7-ones and 4-bromobuthyl acetate or (Z)-4-bromobut-2-en-1-yl acetate.

Author keywords:

Non-Natural Nucleoside; Nucleoside Analog; 1,2,4-Triazolo{[}1,5-a]pyrimidin-7-one; Glycosylation; Alkyl Fragment ANALOGS; GLYCOSYLATION; INHIBITORS; POTENT; ACYCLONUCLEOSIDES; CHEMISTRY

DOI:

10.3987/COM-09-S(S)97

Web of Science ID:

ISI:000276939500040

Соавторы в МНС:

Другие поля

Поле	Значение
Month	MAR 1
Publisher	PERGAMON-ELSEVIER SCIENCE LTD
Address	THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Language	English
Keywords-Plus	ANALOGS; GLYCOSYLATION; INHIBITORS; POTENT; ACYCLONUCLEOSIDES; CHEMISTRY
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Organic
Author-Email	chupakhin@ios.uran.ru
Funding-Acknowledgement	Ministry of Education and Science of Russian Federation {[}5811, 02.512.11]
Funding-Text	This work was financially supported by Ministry of Education and Science of Russian Federation grant No 5811 and State Contract No 02.512.11.
Number-of-Cited-References	33
Usage-Count-Since-2013	2
Journal-ISO	Heterocycles
Doc-Delivery-Number	586UQ