Synthesis and antiviral activity of nucleoside analogs based on 1,2,4-triazolo{[}3,2-c]{[}1,2,4]triazin-7-ones / Rusinov V. L.,Chupakhin O. N.,Deev S. L.,Shestakova T. S.,Ulomskii E. N.,Rusinova L. I.,Kiselev O. I.,Deeva E. G. // RUSSIAN CHEMICAL BULLETIN. - 2010. - V. 59, l. 1. - P. 136-143.

ISSN/EISSN:

1066-5285 / нет данных

Type:

Article

Abstract:

Nucleoside analogs containing hydroxybutyl, hydroxyethoxymethyl, allyloxymethyl, and propargyloxymethyl fragments were synthesized based on 1,2,4-triazolo{[}3,2-c]{[}1,2,4]triazin-7-ones isosteric to purine bases. Some of the compounds obtained inhibit in vitro reproduction of influenza and respiratory syncytial virus infection.

Author keywords:

nucleoside analogs; antiviral drugs; 1,2,4-triazolo{[}3,2-c]{[}1,2,4]triazin-7-one derivatives ACYCLIC NUCLEOSIDES; REPLICATION; INHIBITION

DOI:

10.1007/s11172-010-0056-9

Web of Science ID:

ISI:000277959600016

Соавторы в МНС:

Другие поля

Поле	Значение
Month	JAN
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
Keywords-Plus	ACYCLIC NUCLEOSIDES; REPLICATION; INHIBITION
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	rusinov@mail.ustu.ru deevsl@yandex.ru
Funding-Acknowledgement	President of the Russian Federation {[}3758.2008.3]; Ministry of Science and Education of the Russian Federation {[}02 512 11 2237]
Funding-Text	This work was financially supported by the Council on Grants at the President of the Russian Federation ( Program of State Support for Leading Scientific Schools of the Russian Federation, Grant 3758.2008.3) and the Ministry of Science and Education of the Russian Federation ( State Contract No. 02 512 11 2237).
Number-of-Cited-References	20
Usage-Count-Last-180-days	1
Usage-Count-Since-2013	4
Journal-ISO	Russ. Chem. Bull.
Doc-Delivery-Number	600BZ