A new approach to the synthesis of lamotrigine and other 3,5-diamino-1,2,4-triazine derivatives / Ulomskii EN,Shestakova TS,Deev SL,Rusinov VL,Chupakhin ON // RUSSIAN CHEMICAL BULLETIN. - 2005. - V. 54, l. 3. - P. 726-732.

ISSN/EISSN:

1066-5285 / 1573-9171

Type:

Article

Abstract:

A new in principle method for the synthesis of 6-aryl(hetaryl)-3,5-diamino-1,2,4-triazines by decomposition of pre-synthesized tetrazolo{[}1,5-b]{[}1,2,4]triazines was developed. The advantages of this method over traditional methods were demonstrated using the synthesis of a modern antiepileptic preparation lamotrigine, as an example.

Author keywords:

destruction; 3,5-diamino-1,2,4-triazines; condensation RING; NITROGEN; CLEAVAGE

DOI:

10.1007/s11172-005-0311-7

Web of Science ID:

ISI:000232042300028

Соавторы в МНС:

Другие поля

Поле	Значение
Month	MAR
Publisher	SPRINGER
Address	233 SPRING ST, NEW YORK, NY 10013 USA
Language	English
EISSN	1573-9171
Keywords-Plus	RING; NITROGEN; CLEAVAGE
Research-Areas	Chemistry
Web-of-Science-Categories	Chemistry, Multidisciplinary
Author-Email	rusinov@htf.ustu.ru chupakhin@ios.uran.ru
Number-of-Cited-References	30
Usage-Count-Since-2013	7
Journal-ISO	Russ. Chem. Bull.
Doc-Delivery-Number	966SR