The impact of immunomodulator compound from the group of substituted thiadiazines on the course of stress reaction / Sarapultsev P. A.,Chupakhin O. N.,Medvedeva S. U.,Mukhlynina E. A.,Brilliant S. A.,Sidorova L. P.,Danilova I. G.,Sarapultsev A. P. // INTERNATIONAL IMMUNOPHARMACOLOGY. - 2015. - V. 25, l. 2. - P. 440-449.

ISSN/EISSN:

1567-5769 / 1878-1705

Type:

Article

Abstract:

A significant role of the stress response to many different diseases prompted a search for new specialized and non-specialized anti-stress agents. This study examines the effect of the compound L17 from the group of 5-phenyl substituted-6H-1,3,4-thiadiazine-2-amines, on the manifestations of the stress response. The authors used a standard model of immobilization stress, in which an animal was immobilized on its back for 6 ha day. Parameters of the morphological and functional states of the organs studied were measured and biochemical and enzyme-immunoassays were carried out on the first and second days. This study reveals that the main mechanism by which the L17 compound mediates of its anti-stress was by activation of macrophages on the second day of the experiments and the inhibition of apoptosis in the thymus. The results enable us to suggest that the compound L17 does not improve resistance to stress; however, it does lower the reaction to stress. (C) 2015 Elsevier B.V. All rights reserved.

Author keywords:

Stress; L-17 compound; Thiadiazines; 6H-1,3,4-Thiadiazine; Anti-stress agents TUMOR-NECROSIS-FACTOR; CHRONIC RESTRAINT STRESS; IN-VIVO; INTERLEUKIN-10 PRODUCTION; IMMOBILIZATION STRESS; NEUTROPHIL CHEMOTAXIS; ALVEOLAR MACROPHAGES; IMMUNE-RESPONSE; HUMAN MONOCYTES; GLUCOCORTICOIDS

DOI:

10.1016/j.intimp.2015.02.024

Web of Science ID:

ISI:000352669600025

Соавторы в МНС:

Другие поля

Поле	Значение
Month	APR
Publisher	ELSEVIER SCIENCE BV
Address	PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Language	English
EISSN	1878-1705
Keywords-Plus	TUMOR-NECROSIS-FACTOR; CHRONIC RESTRAINT STRESS; IN-VIVO; INTERLEUKIN-10 PRODUCTION; IMMOBILIZATION STRESS; NEUTROPHIL CHEMOTAXIS; ALVEOLAR MACROPHAGES; IMMUNE-RESPONSE; HUMAN MONOCYTES; GLUCOCORTICOIDS
Research-Areas	Immunology; Pharmacology \& Pharmacy
Web-of-Science-Categories	Immunology; Pharmacology \& Pharmacy
Author-Email	a.sarapultsev@gmail.com
ResearcherID-Numbers	Sarapultsev, Alexey/K-7220-2012 Danilova, Irina/A-7952-2015
ORCID-Numbers	Sarapultsev, Alexey/0000-0003-3101-9655
Funding-Acknowledgement	Institute of Immunology and Physiology, Ural Branch of RAS; Institute of Organic Synthesis, Ural Branch of RAS {[}12-M-34-2064]
Funding-Text	This study was supported by a special research grant of interdisciplinary project of the Institute of Immunology and Physiology and the Institute of Organic Synthesis, Ural Branch of RAS (12-M-34-2064).
Number-of-Cited-References	101
Usage-Count-Last-180-days	5
Usage-Count-Since-2013	18
Journal-ISO	Int. Immunopharmacol.
Doc-Delivery-Number	CF6MA